The crystal structure of the H48Q active site mutant of human group IIA secreted phospholipase A(2) at 1.5 angstrom resolution provides an insight into the catalytic mechanism
The human group IIA secreted PLA2 is a 14 kDa calcium-dependent extracellular enzyme that has been characterized as an acute phase protein with important antimicrobial activity and has been implicated in signal transduction. The selective binding of this enzyme to the phospholipid substrate interfac...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2002-12-01.
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| Subjects: | |
| Online Access: | Get fulltext |