POLG mutations cause decreased mitochondrial DNA repopulation rates following induced depletion in human fibroblasts
Disorders of mitochondrial DNA (mtDNA) maintenance have emerged as an important cause of human genetic disease, but demonstrating the functional consequences of de novo mutations remains a major challenge. We studied the rate of depletion and repopulation of mtDNA in human fibroblasts exposed to eth...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2011.
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| Subjects: | |
| Online Access: | Get fulltext |