The cationic charges on Arg(347), Arg(358) and Arg(449) of human cytochrome P450c17 (CYP17) are essential for the enzyme's cytochrome b(5)-dependent acyl-carbon cleavage activities
CYP17 (17alpha-hydroxylase-17,20-lyase; also P450c17 or P450(17alpha)) catalyses the 17alpha-hydroxylation of progestogens and the subsequent acyl-carbon cleavage of the 17alpha-hydroxylated products (lyase activity) in the biosynthesis of androgens. The enzyme also catalyses another type of acyl-ca...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2004-10.
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| Subjects: | |
| Online Access: | Get fulltext |