Total synthesis of (±)-paroxetine by diastereoconvergent cobalt-catalysed arylation
A total synthesis of paroxetine is reported, with a diastereoselective and diastereoconvergent cobalt-catalysed sp3-sp2 coupling reaction involving a 3-substituted 4-bromo-N-Boc-piperidine (Boc = tert-butoxycarbonyl) substrate as a key step. A 9:1 diastereoselectivity was obtained, while a control e...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2014-07.
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| Subjects: | |
| Online Access: | Get fulltext |