Total synthesis of (±)-paroxetine by diastereoconvergent cobalt-catalysed arylation
A total synthesis of paroxetine is reported, with a diastereoselective and diastereoconvergent cobalt-catalysed sp3-sp2 coupling reaction involving a 3-substituted 4-bromo-N-Boc-piperidine (Boc = tert-butoxycarbonyl) substrate as a key step. A 9:1 diastereoselectivity was obtained, while a control e...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
2014-07.
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Subjects: | |
Online Access: | Get fulltext |