HIF-2α regulates NANOG expression in human embryonic stem cells following hypoxia and reoxygenation through the interaction with an Oct-Sox Cis regulatory element
Low O<sub>2</sub> tension is beneficial for human embryonic stem cell (hESC) maintenance but the mechanism of regulation is unknown. HIF-2α was found to bind directly to predicted hypoxic response elements (HREs) in the proximal promoter of OCT4, NANOG and SOX2 only in hESCs cultured und...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2014-10-01.
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| Subjects: | |
| Online Access: | Get fulltext |