HIF-2α regulates NANOG expression in human embryonic stem cells following hypoxia and reoxygenation through the interaction with an Oct-Sox Cis regulatory element
Low O<sub>2</sub> tension is beneficial for human embryonic stem cell (hESC) maintenance but the mechanism of regulation is unknown. HIF-2α was found to bind directly to predicted hypoxic response elements (HREs) in the proximal promoter of OCT4, NANOG and SOX2 only in hESCs cultured und...
Main Authors: | Petruzzelli, Raffaella (Author), Christensen, David R. (Author), Parry, Kate L. (Author), Sanchez-Elsner, Tilman (Author), Houghton, Franchesca D. (Author) |
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Format: | Article |
Language: | English |
Published: |
2014-10-01.
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Subjects: | |
Online Access: | Get fulltext |
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