Evaluation of the efficacy of ChAd63-MVA vectored vaccines expressing CS & ME-TRAP against controlled human malaria infection in malaria naïve individuals

Evaluation of the efficacy of ChAd63-MVA vectored vaccines expressing CS & ME-TRAP against controlled human malaria infection in malaria naïve individuals

Background.?Circumsporozoite protein (CS) is the antigenic target for RTS,S, the most advanced malaria vaccine to date. Heterologous prime-boost with the viral vectors ChAd63-MVA is the most potent inducer of T-cells in humans, demonstrating significant efficacy when expressing the pre-erythrocytic...

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Main Authors: Hodgson, S.H (Author), Ewer, K.J (Author), Bliss, C.M (Author), Edwards, N.J (Author), Rampling, T. (Author), Anagnostou, N.A (Author), de Barra, E. (Author), Havelock, T. (Author), Bowyer, G. (Author), Poulton, I.D (Author), de Cassan, S. (Author), Illingworth, J.J (Author), Douglas, A.D (Author), Mange, P.B (Author), Collins, K.A (Author), Roberts, R. (Author), Gerry, S. (Author), Berrie, E. (Author), Moyle, S. (Author), Colloca, S. (Author), Cortese, R. (Author), Sinden, R.E (Author), Gilbert, S.C (Author), Bejon, P. (Author), Lawrie, A.M (Author), Nicosia, A. (Author), Faust, S.N (Author), Hill, A.V (Author)
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Language:English
Published: 2015-04-01.
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