The PI3K/mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the E?-TCL1 mouse model

The PI3K/mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the E?-TCL1 mouse model

Current treatment strategies for CLL involve a combination of conventional chemotherapeutics, monoclonal antibodies and targeted signaling inhibitors. However, CLL remains largely incurable with drug resistance and treatment relapse a common occurrence; leading to the search for novel treatments. mT...

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Main Authors: Blunt, Matthew D. (Author), Carter, Matthew J. (Author), Larrayoz, Marta (Author), Smith, Lindsay D. (Author), Aguilar-Hernandez, Maria (Author), Cox, Kerry L. (Author), Tipton, Thomas R.W (Author), Reynolds, Mark (Author), Murphy, Sarah (Author), Lemm, Elizabeth (Author), Dias, Samantha (Author), Duncombe, Andrew S. (Author), Strefford, Jonathan C. (Author), Johnson, Peter W.M (Author), Forconi, Francesco (Author), Stevenson, Freda K. (Author), Packham, Graham (Author), Cragg, Mark S. (Author), Steele, Andrew J. (Author)
Format: Article
Language:English
Published: 2015-06.
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