AMPK activation via modulation of de novo purine biosynthesis with an inhibitor of ATIC homodimerization
5-Aminoimidazole-4-carboxamide ribonucleotide (known as ZMP) is a metabolite produced in de novo purine biosynthesis and histidine biosynthesis, but only utilized in the cell by a homodimeric bifunctional enzyme (called ATIC) that catalyzes the last two steps of de novo purine biosynthesis. ZMP is k...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2015-07-23.
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| Subjects: | |
| Online Access: | Get fulltext |