Biocatalytic route to C-3?-azido/-hydroxy-C-4?-spiro-oxetanoribonucleosides
The lipase, Novozyme®-435, exclusively deacetylates the 5-O-acetyl over 4-C-acetyloxymethyl group of almost identical reactivity in 5-O-acetyl-4-C-acetyloxymethyl-3-azido-3-deoxy-1,2-O-isopropylidene-?-D-ribofuranose that led to the development of first and efficient synthesis of 3?-azido-/3?-amino-...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2015-11-19.
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| Subjects: | |
| Online Access: | Get fulltext |