Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer

Differentiated mammary epithelium shows apicobasal polarity, and loss of tissue organization is an early hallmark of breast carcinogenesis. In BRCA1 mutation carriers, accumulation of stem and progenitor cells in normal breast tissue and increased risk of developing tumors of basal-like type suggest...

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Main Authors: Ashworth, Alan (Author), Maxwell, Christopher A. (Author), Benítez, Javier (Author), Gómez-Baldó, Laia (Author), Osorio, Ana (Author), Bonifaci, Núria (Author), Fernández-Ramires, Ricardo (Author), Costes, Sylvain V. (Author), Guinó, Elisabet (Author), Chen, Helen (Author), Evans, Gareth J. R. (Author), Mohan, Pooja (Author), Català, Isabel (Author), Petit, Anna (Author), Aguilar, Helena (Author), Villanueva, Alberto (Author), Aytes, Alvaro (Author), Serra-Musach, Jordi (Author), Rennert, Gad (Author), Lejbkowicz, Flavio (Author), Peterlongo, Paolo (Author), Manoukian, Siranoush (Author), Peissel, Bernard (Author), Ripamonti, Carla B. (Author), Bonanni, Bernardo (Author), Viel, Alessandra (Author), Allavena, Anna (Author), Bernard, Loris (Author), Radice, Paolo (Author), Friedman, Eitan (Author), Kaufman, Bella (Author), Laitman, Yael (Author), Dubrovsky, Maya (Author), Milgrom, Roni (Author), Jakubowska, Anna (Author), Cybulski, Cezary (Author), Gorski, Bohdan (Author), Jaworska, Katarzyna (Author), Durda, Katarzyna (Author), Sukiennicki, Grzegorz (Author), Lubiński, Jan (Author), Shugart, Yin Yao (Author), Domchek, Susan M. (Author), Letrero, Richard (Author), Weber, Barbara L. (Author), Hogervorst, Frans B. L. (Author), Rookus, Matti A. (Author), Collee, J. Margriet (Author), Devilee, Peter (Author), Ligtenberg, Marjolijn J. (Author), van der Luijt, Rob B. (Author), Aalfs, Cora M. (Author), Waisfisz, Quinten (Author), Wijnen, Juul (Author), van Roozendaal, Cornelis E. P. (Author), Easton, Douglas F. (Author), Peock, Susan (Author), Cook, Margaret (Author), Oliver, Clare (Author), Frost, Debra (Author), Harrington, Patricia (Author), Evans, D. Gareth (Author), Lalloo, Fiona (Author), Eeles, Rosalind (Author), Izatt, Louise (Author), Chu, Carol (Author), Eccles, Diana (Author), Douglas, Fiona (Author), Brewer, Carole (Author), Nevanlinna, Heli (Author), Heikkinen, Tuomas (Author), Couch, Fergus J. (Author), Lindor, Noralane M. (Author), Wang, Xianshu (Author), Godwin, Andrew K. (Author), Caligo, Maria A. (Author), Lombardi, Grazia (Author), Loman, Niklas (Author), Karlsson, Per (Author), Ehrencrona, Hans (Author), von Wachenfeldt, Anna (Author), Bjork Barkardottir, Rosa (Author), Hamann, Ute (Author), Rashid, Muhammad U. (Author), Lasa, Adriana (Author), Caldés, Trinidad (Author), Andrés, Raquel (Author), Schmitt, Michael (Author), Assmann, Volker (Author), Stevens, Kristen (Author), Offit, Kenneth (Author), Curado, João (Author), Tilgner, Hagen (Author), Guigó, Roderic (Author), Aiza, Gemma (Author), Brunet, Joan (Author), Castellsagué, Joan (Author), Martrat, Griselda (Author), Urruticoechea, Ander (Author), Blanco, Ignacio (Author), Tihomirova, Laima (Author), Goldgar, David E. (Author), Buys, Saundra (Author), John, Esther M. (Author), Miron, Alexander (Author), Southey, Melissa (Author), Daly, Mary B. (Author), Schmutzler, Rita K. (Author), Wappenschmidt, Barbara (Author), Meindl, Alfons (Author), Arnold, Norbert (Author), Deissler, Helmut (Author), Varon-Mateeva, Raymonda (Author), Sutter, Christian (Author), Niederacher, Dieter (Author), Imyamitov, Evgeny (Author), Sinilnikova, Olga M. (Author), Stoppa-Lyonne, Dominique (Author), Mazoyer, Sylvie (Author), Verny-Pierre, Carole (Author), Castera, Laurent (Author), de Pauw, Antoine (Author), Bignon, Yves-Jean (Author), Uhrhammer, Nancy (Author), Peyrat, Jean-Philippe (Author), Vennin, Philippe (Author), Fert Ferrer, Sandra (Author), Collonge-Rame (Author), Mortemousque, Isabelle (Author), Spurdle, Amanda B. (Author), Beesley, Jonathan (Author), Chen, Xiaoqing (Author), Healey, Sue (Author), Barcellos-Hoff, Mary Helen (Author), Vidal, Marc (Author), Gruber, Stephen B. (Author), Lázaro, Conxi (Author), Capellá, Gabriel (Author), McGuffog, Lesley (Author), Nathanson, Katherine L. (Author), Antoniou, Antonis C. (Author), Chenevix-Trench, Georgia (Author), Fleisch, Markus C. (Author), Moreno, Víctor (Author), Pujana, Miguel Angel (Author)
Format: Article
Language:English
Published: 2011-11-15.
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