Structural basis for inflammation-driven shedding of CD163 ectodomain and tumor necrosis factor-α in macrophages

Structural basis for inflammation-driven shedding of CD163 ectodomain and tumor necrosis factor-α in macrophages

The haptoglobin-hemoglobin receptor CD163 and proTNF-α are transmembrane macrophage proteins subjected to cleavage by the inflammation-responsive protease ADAM17. This leads to release of soluble CD163 (sCD163) and bioactive TNF-α. Sequence comparison of the juxtamembrane region identified similar p...

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Main Authors: Etzerodt, Anders (Author), Rasmussen, Mie Rostved (Author), Svendsen, Pia (Author), Chalaris, Athena (Author), Schwarz, Jeanette (Author), Galea, Ian (Author), Møller, Holger Jon (Author), Moestrup, Søren Kragh (Author)
Format: Article
Language:English
Published: 2014-01-10.
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