Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline

The pathology of Alzheimer's disease has an inflammatory component that is characterized by upregulation of proinflammatory cytokines, particularly in response to amyloid-? (A?). Using the APPPS1 Alzheimer's disease mouse model, we found increased production of the common interleukin-12 (I...

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Main Authors: vom Berg, Johannes (Author), Prokop, Stefan (Author), Miller, Kelly R. (Author), Obst, Juliane (Author), Kälin, Roland E. (Author), Lopategui-Cabezas, Ileana (Author), Wegner, Anja (Author), Mair, Florian (Author), Schipke, Carola G. (Author), Peters, Oliver (Author), Winter, York (Author), Becher, Burkhard (Author), Heppner, Frank L. (Author)
Format: Article
Language:English
Published: 2012-12.
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