Exon-centric regulation of ATM expression is population-dependent and amenable to antisense modification by pseudoexon targeting
ATM is an important cancer susceptibility gene that encodes a critical apical kinase of the DNA damage response (DDR) pathway. We show that a key nonsense-mediated RNA decay switch exon (NSE) in ATM is repressed by U2AF, PUF60 and hnRNPA1. The NSE activation was haplotype-specific and was most promo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2016-01-06.
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| Subjects: | |
| Online Access: | Get fulltext |