Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma

Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma

We performed FISH for 16q23 abnormalities in 861 patients with newly diagnosed multiple myeloma and identified del(16q) in 19.5%. In 467 cases in which demographic and survival data were available, del(16q) was associated with a worse overall survival. It was an independent prognostic marker and con...

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Main Authors: Jenner, Matthew W. (Author), Leone, Paola E. (Author), Walker, Brian A. (Author), Ross, Fiona M. (Author), Johnson, David C. (Author), Gonzalez, David (Author), Chiecchio, Laura (Author), Dachs Cabanas, Elisabet (Author), Dagrada, Gian Paolo (Author), Nightingale, Mathew (Author), Protheroe, Rebecca K.M (Author), Stockley, David (Author), Else, Monica (Author), Dickens, Nicholas J. (Author), Cross, Nicholas C.P (Author), Davies, Faith E. (Author), Morgan, Gareth J. (Author)
Format: Article
Language:English
Published: 2007-07-03.
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