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01322 am a22001573u 4500 |
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62962 |
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|a Underwood, Timothy J.
|e author
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|a Amin, Jay
|e author
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|a Lillycrop, Karen A.
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|a Blaydes, Jeremy P.
|e author
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|a Dissection of the functional interaction between p53 and the embryonic proto-oncoprotein PAX3
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|c 2007-12-22.
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|z Get fulltext
|u https://eprints.soton.ac.uk/62962/1/Underwood_FEBS__v2.pdf
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|a Studies from murine embryogenesis and cancer cells derived from human melanomas have identified a critical role for the transcription factor PAX3 in the suppression of p53 protein accumulation and p53-dependent apoptosis. Here we show, using a well-defined over-expression system, that PAX3 suppresses p53-dependent transcription from promoters of p53-responsive genes, notably BAX and HDM2-P2, and reduces p53 protein abundance by promoting its degradation. We de. ne the functional domains of PAX3 required for this activity, and furthermore present evidence that PAX3-dependent inhibition of p53 is independent of binding of the N-terminal domain of p53 to HDM2, the primary negative regulator of cellular p53 activity. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved
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