Dissection of the functional interaction between p53 and the embryonic proto-oncoprotein PAX3
Studies from murine embryogenesis and cancer cells derived from human melanomas have identified a critical role for the transcription factor PAX3 in the suppression of p53 protein accumulation and p53-dependent apoptosis. Here we show, using a well-defined over-expression system, that PAX3 suppresse...
Main Authors: | Underwood, Timothy J. (Author), Amin, Jay (Author), Lillycrop, Karen A. (Author), Blaydes, Jeremy P. (Author) |
---|---|
Format: | Article |
Language: | English |
Published: |
2007-12-22.
|
Subjects: | |
Online Access: | Get fulltext |
Similar Items
-
Inhibition of p53 function in tumours that express the PAX3 proto-oncogene
by: Underwood, Timothy James
Published: (2006) -
The expression of the developmentally regulated proto-oncogene Pax-3 is modulated by N-Myc
by: Harris, Robert G., et al.
Published: (2002) -
Molecular characterisation of the human proto-oncoprotein, PML
by: Boddy, Michael Nicholas
Published: (1996) -
Investigation of the synovial sarcoma proto-oncoprotein SYT
by: Perani, Michela
Published: (2005) -
Investigation of the SYT and SYT-SSX2 proto-oncoproteins in synovial sarcoma
by: Vaughan, Lynsey Sian
Published: (2010)