Ceramide-induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation
Ceramide, the central molecule of the sphingomyelin pathway, serves as a second messenger for cellular functions ranging from proliferation and differentiation to growth arrest and apoptosis. In this study we show that c2-ceramide induces apoptosis in primary cortical neuron cultures and that this e...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2001-02.
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| Subjects: | |
| Online Access: | Get fulltext |