In vivo retargeting of adenovirus type 5 to ?v?6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery

A key impediment to successful cancer therapy with adenoviral vectors is the inefficient transduction of malignant tissue in vivo. Compounding this problem is the lack of cancer-specific targets, coupled with a shortage of corresponding high-efficiency ligands, permitting selective retargeting. The...

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Main Authors: Coughlan, Lynda (Author), Vallath, Sabari (Author), Saha, Antonio (Author), Flak, Magdalena (Author), MacNeish, Ian A. (Author), Vassaux, Georges (Author), Marshall, John F. (Author), Hart, Ian R. (Author), Thomas, Gareth J. (Author)
Format: Article
Language:English
Published: 2009-07.
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