In vivo retargeting of adenovirus type 5 to ?v?6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery
A key impediment to successful cancer therapy with adenoviral vectors is the inefficient transduction of malignant tissue in vivo. Compounding this problem is the lack of cancer-specific targets, coupled with a shortage of corresponding high-efficiency ligands, permitting selective retargeting. The...
Main Authors: | Coughlan, Lynda (Author), Vallath, Sabari (Author), Saha, Antonio (Author), Flak, Magdalena (Author), MacNeish, Ian A. (Author), Vassaux, Georges (Author), Marshall, John F. (Author), Hart, Ian R. (Author), Thomas, Gareth J. (Author) |
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Format: | Article |
Language: | English |
Published: |
2009-07.
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Subjects: | |
Online Access: | Get fulltext |
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