Inhibition of prostaglandin E-2 production by synthetic minor prenylated chalcones and flavonoids: Synthesis, biological activity, crystal structure, and in silico evaluation

The discovery of potent inhibitors of prostaglandin E-2 (PGE(2)) synthesis in recent years has been proven to be an important game changer in pharmaceutical industry. It is known that excessive production of PGE(2) triggers a vast array of biological signals and physiological events that contributes...

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Main Authors: Abas, F (Author), Ahmad, S (Author), Aluwi, MFFM (Author), Bahari, MNA (Author), Ismail, NH (Author), Jantan, I (Author), Rullah, K (Author), Wai, LK (Author), Wei, LS (Author), Yamin, BM (Author)
Format: Article
Language:English
Online Access:View Fulltext in Publisher