Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E-2 production in LPS-induced murine and human macrophages cell lines

Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E-2 production in LPS-induced murine and human macrophages cell lines

The syntheses and bioactivities of symmetrical curcumin and its analogues have been the subject of interest by many medicinal chemists and pharmacologists over the years. To improve our understanding, we have synthesized a series of unsymmetrical monocarbonyl curcumin analogues and evaluated their e...

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Bibliographic Details
Main Authors: Abas, F (Author), Aluwi, MFFM (Author), Bahari, MNA (Author), Faudzi, SMM (Author), Fauzi, NM (Author), Ismail, NH (Author), Jalil, J (Author), Jantan, I (Author), Lam, KW (Author), Leong, SW (Author), Lim, SJ (Author), Rullah, K (Author), Yamin, BM (Author)
Format: Article
Language:English
Published: 2016
Subjects:
ANTIINFLAMMATORY AGENTS
ANTIOXIDANT
BIOLOGICAL EVALUATION
Cyclooxygenase-2
DERIVATIVES
DIARYLPENTANOID ANALOGS
DOCKING
E SYNTHASE-1
LIPOXYGENASE
NITRIC-OXIDE
Prostaglandin E-2
RAW264.7
Single-crystal XRD
STABILITY
U937
Unsymmetrical curcumin analogues
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