Safety of Proton Pump Inhibitors Based on a Large, Multi-Year, Randomized Trial of Patients Receiving Rivaroxaban or Aspirin

Safety of Proton Pump Inhibitors Based on a Large, Multi-Year, Randomized Trial of Patients Receiving Rivaroxaban or Aspirin

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BACKGROUND & AIMS: Proton pump inhibitors (PPIs) are effective at treating acid-related disorders. These drugs are well tolerated in the short term, but long-term treatment was associated with adverse events in observational studies. We aimed to confirm these findings in an adequately powered ra...

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Main Authors: COMPASS Investigators, Alings, M (Author), Anand, SS (Author), Avezum, A (Author), Bhatt, DL (Author), Bosch, J (Author), Branch, KRH (Author), Bruns, NC (Author), Commerford, PJ (Author), Connolly, SJ (Author), Dagenais, GR (Author), Dans, AL (Author), Diaz, R (Author), Dyal, L (Author), Eikelboom, JW (Author), Ertl, G (Author), Felix, C (Author), Fox, KAA (Author), Guzik, TJ (Author), Hart, RG (Author), Hori, M (Author), Kakkar, AK (Author), Keltai, M (Author), Kim, JH (Author), Lanas, F (Author), Leong, D (Author), Lewis, BS (Author), Liang, Y (Author), Lonn, EM (Author), Lopez-Jaramillo, P (Author), Maggioni, AP (Author), Metsarinne, KP (Author), Moayyedi, P (Author), Muehlhofer, E (Author), O'Donnell, M (Author), Parkhomenko, AN (Author), Piegas, LS (Author), Pogosova, N (Author), Probstfield, J (Author), Ryden, L (Author), Shestakovska, O (Author), Steg, PG (Author), Stork, S (Author), Tonkin, AM (Author), Torp-Pedersen, C (Author), Verhamme, PB (Author), Vinereanu, D (Author), Widimsky, P (Author), Yusoff, K (Author), Yusuf, S (Author), Zhu, J (Author)
Format: Article
Language:English
Published: 2019
Subjects:
ASSOCIATION
Bacteria
CVD
INFECTION
MANAGEMENT
OMEPRAZOLE
Reflux
RISK-FACTOR
THERAPY
Thrombosis
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