Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance

Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance

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While age-related insulin resistance and hyperinsulinemia are usually considered to be secondary to changes in muscle, the liver also plays a key role in whole-body insulin handling and its role in age-related changes in insulin homeostasis is largely unknown. Here, we show that patent pores called...

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Bibliographic Details
Main Authors: Boyer, D (Author), Cogger, VC (Author), Cordwell, SJ (Author), Das, A (Author), de Cabo, R (Author), Fraser, R (Author), Hilmer, SN (Author), Le Couteur, DG (Author), Li, SYC (Author), Mach, J (Author), Mitchell, SJ (Author), Mohamad, M (Author), Nines, D (Author), Simpson, SJ (Author), Sinclair, DA (Author), Solon-Biet, SM (Author), Warren, A (Author), White, MY (Author), Wu, LE (Author)
Format: Article
Language:English
Published: 2016
Subjects:
ADIPOSE-TISSUE
ageing
aging
ATHEROSCLEROSIS
endothelium
FATTY LIVER
fenestrae
fenestrations
hyperinsulinemia
HYPERLIPIDEMIA
METABOLISM
MODEL
OLD-AGE
POLOXAMER 407
SIEVE
SINUSOIDAL ENDOTHELIUM
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