4-(2-(1H-Benzo[d]imidazol-2-ylthio)acetamido)-N-(substituted phenyl)benzamides: design, synthesis and biological evaluation

4-(2-(1H-Benzo[d]imidazol-2-ylthio)acetamido)-N-(substituted phenyl)benzamides: design, synthesis and biological evaluation

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Background: Dihydrofolate reductase (DHFR) is an important target for antimetabolite class of antimicrobials because it participates in purine synthesis. 2-mercaptobenzimidazole (2MBI) has similar structural features as purine nucleotides. Given that benzimidazole and similar heteroaromatics have be...

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Bibliographic Details
Main Authors: Lim, SM (Author), Mani, V (Author), Narasimhan, B (Author), Ramasamy, K (Author), Shah, SAA (Author), Tahlan, S (Author)
Format: Article
Language:English
Published: 2019
Subjects:
2-Mercaptobenzimidazole derivatives
Antibacterial
ANTIBACTERIAL
Anticancer
Antifungal
ANTIMICROBIAL ACTIVITY
BENZIMIDAZOLE DERIVATIVES
p-Amino benzoic acid
QSAR
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Internet

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