Structure-activity relationship and in silico study of unique bi-heterocycles: 5-[(2-amino-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazole-2-thiol derivatives

Structure-activity relationship and in silico study of unique bi-heterocycles: 5-[(2-amino-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazole-2-thiol derivatives

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This paper presents the synthesis of some unique bi-heterocyclic hybrid molecules with a thiazole and an oxadiazole ring. The synthesis was initiated by the conversion of ethyl 2-(2-amino-1,3-thiazol-4-yl)acetate (1) to the corresponding 2-(2-amino-1,3-thiazol-4-yl)acetohydrazide (2) by the reaction...

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Bibliographic Details
Main Authors: Abbasi, MA (Author), Aziz-Ur-Rehman (Author), Hassan, M (Author), Mirza, B (Author), Ramzan, MS (Author), Raza, H (Author), Seo, SY (Author), Shah, SAA (Author), Siddiqui, SZ (Author)
Format: Article
Language:English
Published: 2019
Subjects:
1,3,4-oxadiazole
1,3-thiazole
acetylcholinesterase
brine shrimps
butyrylcholinesterase
glucosidase
HYBRID OXADIAZOLE SCAFFOLDS
INHIBITORS
molecular docking
urease
UREASE
VITRO
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