BIOASSAY-GUIDED ISOLATION OF OCHROLIFUANINE: A BISINDOLE ALKALOID OF DYERA COSTULATA ACTIVE ON TRYPANOSOMA BRUCEI BRUCEI

BIOASSAY-GUIDED ISOLATION OF OCHROLIFUANINE: A BISINDOLE ALKALOID OF DYERA COSTULATA ACTIVE ON TRYPANOSOMA BRUCEI BRUCEI

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Dyera costulata, locally known as jelutong, have shown promising in vitro inhibitory activity against Trypanosoma brucei brucei strain BS221. The methanolic leaf extract, evaluated using Alamar Blue Assay, showed strong antitrypanosomal activity (IC50 0.58 +/- 0.01 mu g mL(-1)) and high selectivity...

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Bibliographic Details
Main Authors: Getha, K (Author), Lili-Sahira, H (Author), Mohd-Hafidz-Hadi, A (Author), Mohd-Ilham, A (Author), Muhd-Haffiz, J (Author), Muhd-Syamil, A (Author), Norhayati, I (Author), Nurhayati, ZA (Author)
Format: Article
Language:English
Published: 2018
Subjects:
2-SUBSTITUTED QUINOLINES
AFRICAN TRYPANOSOMES
Antitrypanosomal activity
Apocynaceae
APOCYNACEAE
DISCOVERY
DRUGS
MEDICINAL-PLANTS
NATURAL-PRODUCTS
PROTOZOAN NEGLECTED DISEASES
RHODESIENSE
SECONDARY METABOLITES
selectivity index (SI)
total alkaloid extract
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