BIOASSAY-GUIDED ISOLATION OF OCHROLIFUANINE: A BISINDOLE ALKALOID OF DYERA COSTULATA ACTIVE ON TRYPANOSOMA BRUCEI BRUCEI

Dyera costulata, locally known as jelutong, have shown promising in vitro inhibitory activity against Trypanosoma brucei brucei strain BS221. The methanolic leaf extract, evaluated using Alamar Blue Assay, showed strong antitrypanosomal activity (IC50 0.58 +/- 0.01 mu g mL(-1)) and high selectivity...

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Main Authors:	Getha, K (Author), Lili-Sahira, H (Author), Mohd-Hafidz-Hadi, A (Author), Mohd-Ilham, A (Author), Muhd-Haffiz, J (Author), Muhd-Syamil, A (Author), Norhayati, I (Author), Nurhayati, ZA (Author)
Format:	Article
Language:	English
Published:	2018
Subjects:	2-SUBSTITUTED QUINOLINES AFRICAN TRYPANOSOMES Antitrypanosomal activity Apocynaceae APOCYNACEAE DISCOVERY DRUGS MEDICINAL-PLANTS NATURAL-PRODUCTS PROTOZOAN NEGLECTED DISEASES RHODESIENSE SECONDARY METABOLITES selectivity index (SI) total alkaloid extract
Online Access:	View Fulltext in Publisher

Bioassay-guided isolation of ochrolifuanine: A bisindole alkaloid of Dyera costulata active on Trypanosoma brucei brucei

by Getha, K., Lili-Sahira, H., Mohd-Hafidz-Hadi, A., Mohd-Ilham, A., Muhd-Haffiz, J., Muhd-Syamil, A., Norhayati, I., Nurhayati, Z.A
Published 2018

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BIOASSAY-GUIDED ISOLATION OF OCHROLIFUANINE: A BISINDOLE ALKALOID OF DYERA COSTULATA ACTIVE ON TRYPANOSOMA BRUCEI BRUCEI

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