Catalpol Ameliorates Insulin Sensitivity and Mitochondrial Respiration in Skeletal Muscle of Type-2 Diabetic Mice Through Insulin Signaling Pathway and AMPK/SIRT1/PGC-1 alpha/PPAR-gamma Activation

Catalpol Ameliorates Insulin Sensitivity and Mitochondrial Respiration in Skeletal Muscle of Type-2 Diabetic Mice Through Insulin Signaling Pathway and AMPK/SIRT1/PGC-1 alpha/PPAR-gamma Activation

Catalpol was tested for various disorders including diabetes mellitus. Numerous molecular mechanisms have emerged supporting its biological effects but with little information towards its insulin sensitizing effect. In this study, we have investigated its effect on skeletal muscle mitochondrial resp...

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Bibliographic Details
Main Authors: Bhattamisra, SK (Author), Candasamy, M (Author), Majeed, AA (Author), Shadab, M (Author), Tan, SC (Author), Yap, KH (Author), Yee, GS (Author)
Format: Article
Language:English
Published: 2020
Subjects:
BIOGENESIS
catalpol
COACTIVATOR
FAT
glucose homeostasis
GLUCOSE-TOLERANCE
insulin sensitivity
insulin signaling pathway
MELLITUS
mitochondrial respiration
oxygen consumption rate
PGC-1-ALPHA
PHOSPHATIDYLINOSITOL 3-KINASE
PROTEIN-KINASE-C
RESISTANCE
ROS PRODUCTION
type-2 diabetes mellitus
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