Monoamine Oxidase Inhibition by Major Tanshinones from Salvia miltiorrhiza and Selective Muscarinic Acetylcholine M-4 Receptor Antagonism by Tanshinone I

Monoamine Oxidase Inhibition by Major Tanshinones from Salvia miltiorrhiza and Selective Muscarinic Acetylcholine M-4 Receptor Antagonism by Tanshinone I

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Monoamine oxidases (MAOs) and muscarinic acetylcholine receptors (mAChRs) are considered important therapeutic targets for Parkinson's disease (PD). Lipophilic tanshinones are major phytoconstituents in the dried roots of Salvia miltiorrhiza that have demonstrated neuroprotective effects agains...

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Bibliographic Details
Main Authors: Choi, JS (Author), Fauzi, FM (Author), Jung, HA (Author), Park, SE (Author), Paudel, P (Author), Prajapati, R (Author), Seong, SH (Author)
Format: Article
Language:English
Published: 2021
Subjects:
DESIGN
DOCKING
DOPAMINERGIC-NEURONS
IIA PROTECTS
M-4 receptor antagonist
MAO-A
MEMORY
MODEL
molecular docking
monoamine oxidase inhibition
Parkinson's disease
PREVENTS
SILICO
tanshinone I
TARGET
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