Synthesis, Molecular Docking, and Antimalarial Activity of Hybrid 4-Aminoquinoline-pyrano[2,3-c]pyrazole Derivatives

Synthesis, Molecular Docking, and Antimalarial Activity of Hybrid 4-Aminoquinoline-pyrano[2,3-c]pyrazole Derivatives

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Widespread resistance of Plasmodium falciparum to current artemisinin-based combination therapies necessitate the discovery of new medicines. Pharmacophoric hybridization has become an alternative for drug resistance that lowers the risk of drug-drug adverse interactions. In this study, we synthesiz...

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Bibliographic Details
Main Authors: Abd Razak, MRM (Author), Agustar, HK (Author), Ali, AH (Author), Hamzah, AS (Author), Hassan, NI (Author), Lam, KW (Author), Latip, J (Author), Mark-Lee, WF (Author), Mohammat, MF (Author), Shaameri, Z (Author), Shamsuddin, MA (Author), Zakaria, NH (Author)
Format: Article
Language:English
Published: 2021
Subjects:
4-aminoquinoline
antimalarial
ANTIPLASMODIAL ACTIVITY
BIOLOGICAL EVALUATION
DESIGN
docking
DRUG DISCOVERY
hybrid
IN-VITRO
MALARIA
MODE
PLASMODIUM-FALCIPARUM
pyrano[2,3-c]pyrazole
PYRAZOLE
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