Ursodeoxycholic acid upregulates ERK and Akt in the protection of cardiomyocytes against CoCl2

Ursodeoxycholic acid upregulates ERK and Akt in the protection of cardiomyocytes against CoCl2

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Ursodeoxycholic acid (UDCA) is used to treat liver diseases and demonstrates cardioprotective effects. Accumulation of the plasma membrane sphingolipid sphingomyelin in the heart can lead to atherosclerosis and coronary artery disease. Sphingomyelinases (SMases) break down sphingomyelin, producing c...

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Bibliographic Details
Main Authors: Ab Rahim, S (Author), Hanafi, NI (Author), Hasani, NAH (Author), Kadir, SHSA (Author), Mohamed, AS (Author), Noor, JM (Author), Osman, NJ (Author), Siran, R (Author)
Format: Article
Language:English
Published: 2016
Subjects:
ACTIVATION
APOPTOSIS
BILE-ACIDS
Cardiomyocytes
CELL-DEATH
HEART
HYPERTROPHY
Hypoxia
HYPOXIA
INHIBITION
INJURY
NEUTRAL SPHINGOMYELINASE
Sphingomyelinases
Ursodeoxycholic acid
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