Ursodeoxycholic acid upregulates ERK and Akt in the protection of cardiomyocytes against CoCl2

Ursodeoxycholic acid upregulates ERK and Akt in the protection of cardiomyocytes against CoCl2

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Ursodeoxycholic acid (UDCA) is used to treat liver diseases and demonstrates cardioprotective effects. Accumulation of the plasma membrane sphingolipid sphingomyelin in the heart can lead to atherosclerosis and coronary artery disease. Sphingomyelinases (SMases) break down sphingomyelin, producing c...

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Bibliographic Details
Main Authors:	Ab Rahim, S (Author), Hanafi, NI (Author), Hasani, NAH (Author), Kadir, SHSA (Author), Mohamed, AS (Author), Noor, JM (Author), Osman, NJ (Author), Siran, R (Author)
Format:	Article
Language:	English
Published:	2016
Subjects:	ACTIVATION APOPTOSIS BILE-ACIDS Cardiomyocytes CELL-DEATH HEART HYPERTROPHY Hypoxia HYPOXIA INHIBITION INJURY NEUTRAL SPHINGOMYELINASE Sphingomyelinases Ursodeoxycholic acid
Online Access:	View Fulltext in Publisher

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