Adjuvants and immunization strategies to induce influenza virus hemagglutinin stalk antibodies.

by Peter H Goff, Dirk Eggink, Christopher W Seibert, Rong Hai, Luis Martínez-Gil, Florian Krammer, Peter Palese
Published 2013-01-01

Age Dependence and Isotype Specificity of Influenza Virus Hemagglutinin Stalk-Reactive Antibodies in Humans

by Raffael Nachbagauer, Angela Choi, Ruvim Izikson, Manon M. Cox, Peter Palese, Florian Krammer
Published 2016-01-01

Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies

by Norbert Pardi, Kaela Parkhouse, Ericka Kirkpatrick, Meagan McMahon, Seth J. Zost, Barbara L. Mui, Ying K. Tam, Katalin Karikó, Christopher J. Barbosa, Thomas D. Madden, Michael J. Hope, Florian Krammer, Scott E. Hensley, Drew Weissman
Published 2018-08-01

An immuno-assay to quantify influenza virus hemagglutinin with correctly folded stalk domains in vaccine preparations.

by Madhusudan Rajendran, Weina Sun, Phillip Comella, Raffael Nachbagauer, Teddy John Wohlbold, Fatima Amanat, Ericka Kirkpatrick, Peter Palese, Florian Krammer
Published 2018-01-01

An Inactivated Influenza Virus Vaccine Approach to Targeting the Conserved Hemagglutinin Stalk and M2e Domains

by Weina Sun, Allen Zheng, Robert Miller, Florian Krammer, Peter Palese
Published 2019-09-01

A carboxy-terminal trimerization domain stabilizes conformational epitopes on the stalk domain of soluble recombinant hemagglutinin substrates.

by Florian Krammer, Irina Margine, Gene S Tan, Natalie Pica, Jens C Krause, Peter Palese
Published 2012-01-01

Introduction of Cysteines in the Stalk Domain of Recombinant Influenza Virus N1 Neuraminidase Enhances Protein Stability and Immunogenicity in Mice

by Shirin Strohmeier, Juan Manuel Carreño, Ruhi Nichalle Brito, Florian Krammer
Published 2021-04-01

Development and Assessment of a Pooled Serum as Candidate Standard to Measure Influenza A Virus Group 1 Hemagglutinin Stalk-Reactive Antibodies

by Juan Manuel Carreño, Jacqueline U. McDonald, Tara Hurst, Peter Rigsby, Eleanor Atkinson, Lethia Charles, Raffael Nachbagauer, Mohammad Amin Behzadi, Shirin Strohmeier, Lynda Coughlan, Teresa Aydillo, Boerries Brandenburg, Adolfo García-Sastre, Krisztian Kaszas, Min Z. Levine, Alessandro Manenti, Adrian B. McDermott, Emanuele Montomoli, Leacky Muchene, Sandeep R. Narpala, Ranawaka A. P. M. Perera, Nadine C. Salisch, Sophie A. Valkenburg, Fan Zhou, Othmar G. Engelhardt, Florian Krammer
Published 2020-11-01

Influenza Virus Hemagglutinin Stalk-Specific Antibodies in Human Serum are a Surrogate Marker for In Vivo Protection in a Serum Transfer Mouse Challenge Model

by Henning Jacobsen, Madhusudan Rajendran, Angela Choi, Haakon Sjursen, Karl A. Brokstad, Rebecca J. Cox, Peter Palese, Florian Krammer, Raffael Nachbagauer, Rino Rappuoli
Published 2017-09-01

Globular Head-Displayed Conserved Influenza H1 Hemagglutinin Stalk Epitopes Confer Protection against Heterologous H1N1 Virus.

by Miriam Klausberger, Rupert Tscheliessnig, Silke Neff, Raffael Nachbagauer, Teddy John Wohlbold, Monika Wilde, Dieter Palmberger, Florian Krammer, Alois Jungbauer, Reingard Grabherr
Published 2016-01-01

Vaccination With Viral Vectors Expressing Chimeric Hemagglutinin, NP and M1 Antigens Protects Ferrets Against Influenza Virus Challenge

by Meagan McMahon, Guha Asthagiri Arunkumar, Guha Asthagiri Arunkumar, Wen-Chun Liu, Wen-Chun Liu, Daniel Stadlbauer, Daniel Stadlbauer, Randy A. Albrecht, Randy A. Albrecht, Vincent Pavot, Mario Aramouni, Teresa Lambe, Sarah C. Gilbert, Florian Krammer
Published 2019-08-01

Chimeric Hemagglutinin-Based Live-Attenuated Vaccines Confer Durable Protective Immunity against Influenza A Viruses in a Preclinical Ferret Model

by Wen-Chun Liu, Raffael Nachbagauer, Daniel Stadlbauer, Shirin Strohmeier, Alicia Solórzano, Francesco Berlanda-Scorza, Bruce L. Innis, Adolfo García-Sastre, Peter Palese, Florian Krammer, Randy A. Albrecht
Published 2021-01-01

Sequential Immunization With Live-Attenuated Chimeric Hemagglutinin-Based Vaccines Confers Heterosubtypic Immunity Against Influenza A Viruses in a Preclinical Ferret Model

by Wen-Chun Liu, Wen-Chun Liu, Raffael Nachbagauer, Daniel Stadlbauer, Alicia Solórzano, Francesco Berlanda-Scorza, Adolfo García-Sastre, Adolfo García-Sastre, Adolfo García-Sastre, Peter Palese, Peter Palese, Florian Krammer, Randy A. Albrecht, Randy A. Albrecht
Published 2019-04-01

Cryo-electron Microscopy Structures of Chimeric Hemagglutinin Displayed on a Universal Influenza Vaccine Candidate

by Erin E. H. Tran, Kira A. Podolsky, Alberto Bartesaghi, Oleg Kuybeda, Giovanna Grandinetti, Teddy John Wohlbold, Gene S. Tan, Raffael Nachbagauer, Peter Palese, Florian Krammer, Sriram Subramaniam
Published 2016-03-01

A Universal Influenza Virus Vaccine Candidate Tested in a Pig Vaccination-Infection Model in the Presence of Maternal Antibodies

by Sun-Young Sunwoo, Michael Schotsaert, Igor Morozov, Anne Sally Davis, Yuhao Li, Jinhwa Lee, Chester McDowell, Philip Meade, Raffael Nachbagauer, Adolfo García-Sastre, Wenjun Ma, Florian Krammer, Juergen A. Richt
Published 2018-09-01

No evidence of antigenic seniority in hemagglutinin specific antibody responses after adjuvanted pandemic 2009 influenza vaccination

by Anders Madsen, Linda Azimi, Sarah Tete, Fan Zhou, Florian Krammer, Rebecca Jane Cox, Åsne Jul-Larsen
Published 2019-08-01

Broad cross-reactive IgG responses elicited by adjuvanted vaccination with recombinant influenza hemagglutinin (rHA) in ferrets and mice.

by Jiong Wang, Shannon P Hilchey, Marta DeDiego, Sheldon Perry, Ollivier Hyrien, Aitor Nogales, Jessica Garigen, Fatima Amanat, Nelson Huertas, Florian Krammer, Luis Martinez-Sobrido, David J Topham, John J Treanor, Mark Y Sangster, Martin S Zand
Published 2018-01-01

A Live-Attenuated Prime, Inactivated Boost Vaccination Strategy with Chimeric Hemagglutinin-Based Universal Influenza Virus Vaccines Provides Protection in Ferrets: A Confirmatory...

by Raffael Nachbagauer, Florian Krammer, Randy A. Albrecht
Published 2018-07-01

Analysis of Anti-Influenza Virus Neuraminidase Antibodies in Children, Adults, and the Elderly by ELISA and Enzyme Inhibition: Evidence for Original Antigenic Sin

by Madhusudan Rajendran, Raffael Nachbagauer, Megan E. Ermler, Paul Bunduc, Fatima Amanat, Ruvim Izikson, Manon Cox, Peter Palese, Maryna Eichelberger, Florian Krammer, Joseph Bresee, Keith P. Klugman
Published 2017-03-01

Persistently high antibody responses after AS03-adjuvanted H1N1pdm09 vaccine: Dissecting the HA specific antibody response

by Anders Madsen, Åsne Jul-Larsen, Mai-Chi Trieu, Florian Krammer, Rebecca J. Cox
Published 2021-04-01