Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells

by Mueller, Stephanie, Vrbanac, Vlad, Genel, Shy, Tager, Andrew M., Allen, Todd M., Jones, Richard Bradley, Kumari, Sudha, Walker, Bruce, Irvine, Darrell J
Published 2018

Convolution of chemoattractant secretion rate, source density, and receptor desensitization direct diverse migration patterns in leukocytes

by Wang, Yana, Irvine, Darrell J
Published 2014

Rapid Conformational Epitope Mapping of Anti-gp120 Antibodies with a Designed Mutant Panel Displayed on Yeast

by Mata-Fink, Jordi, Kriegsman, Barry, Yu, Hui Xin, Zhu, Hanna, Wittrup, Karl Dane, Hanson, Melissa Catherine, Irvine, Darrell J
Published 2015

Stochastic Particle Barcoding for Single-Cell Tracking and Multiparametric Analysis

by Castellarnau, Marc, Su, Hao-wei, Tokatlian, Talar, Voldman, Joel, Szeto, Gregory, Love, John C, Irvine, Darrell J
Published 2015

Controlling timing and location in vaccines

by Irvine, Darrell J, Aung, Aereas, Silva, Murillo
Published 2020

Guiding Principles in the Design of Molecular Bioconjugates for Vaccine Applications

by Liu, Haipeng, Irvine, Darrell J
Published 2017

Temporally Programmed CD8α[superscrip +] DC Activation Enhances Combination Cancer Immunotherapy

by Szeto, Gregory L., Overwijk, Willem W., Tzeng, Alice, Kauke, Monique Jacqueline, Zhu, Eric Franklin, Moynihan, Kelly Dare, Opel, Cary Francis, Yang, Nicole Jie Yeon, Mehta, Naveen, Irvine, Darrell J, Wittrup, Karl Dane
Published 2017

In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles

by Jewell, Christopher M., Irvine, Darrell J, Bustamante Lopez, Sandra C
Published 2012

Localized Immunotherapy via Liposome-Anchored Anti-CD137 + IL-2 Prevents Lethal Toxicity and Elicits Local and Systemic Antitumor Immunity

by Kwong, Brandon, Gai, S. Annie, Elkhader, Jamal, Wittrup, Karl Dane, Irvine, Darrell J
Published 2014

Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses

by Cochran, Jennifer R, Moynihan, Kelly Dare, Opel, Cary Francis, Szeto, Gregory, Tzeng, Alice, Zhu, Eric Franklin, Engreitz, Jesse Michael, Williams, Robert T., Rakhra, Kavya, Zhang, Michael H, Rothschilds, Adrienne Marie, Kumari, Sudha, Kelly, Ryan Lewis, Kwan, Byron Hua, Abraham, Wuhbet, Hu, Kevin, Mehta, Naveen, Kauke, Monique Jacqueline, Suh, Heikyung, Lauffenburger, Douglas A, Wittrup, Karl Dane, Irvine, Darrell J
Published 2017

Engulfing tumors with synthetic extracellular matrices for cancer

by Hori, Yuki, Stern, Patrick, Hynes, Richard O, Irvine, Darrell J
Published 2012

Releasable Layer-by-Layer Assembly of Stabilized Lipid Nanocapsules on Microneedles for Enhanced Transcutaneous Vaccine Delivery

by DeMuth, Peter Charles, Moon, James J., Suh, Heikyung, Hammond, Paula T, Irvine, Darrell J
Published 2014

In vivo targeting of adoptively transferred T-cells with antibody- and cytokine-conjugated liposomes

by Zheng, Yiran, Stephan, Matthias T., Gai, S. Annie, Abraham, Wuhbet, Shearer, Adrianne, Zheng, Yiran, Irvine, Darrell J
Published 2014

Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles

by Stephan, Matthias T., Stephan, Sirkka B., Bak, Peter, Chen, Jianzhu, Irvine, Darrell J
Published 2015

Enhancement of Peptide Vaccine Immunogenicity by Increasing Lymphatic Drainage and Boosting Serum Stability

by Karver, Mark R., Dinter, Jens, Gall, Sylvie Le, Moynihan, Kelly Dare, Holden, Rebecca Lynn, Mehta, Naveen, Wang, Chensu, Liang, Simon, Abraham, Wuhbet, Melo, Mariane Bandeira, Zhang, Angela Q., Li, Na, Pentelute, Bradley L., Irvine, Darrell J
Published 2018

Shaping humoral immunity to vaccines through antigen-displaying nanoparticles

by Irvine, Darrell J, Read, Benjamin J.
Published 2020

Cytoskeletal tension actively sustains the migratory T‐cell synaptic contact

by Kumari, Sudha, Mak, Michael, Poh, Yeh Chuin, Tohme, Mira, Watson, Nicki, Melo, Mariane Bandeira, Janssen, Erin, Dustin, Michael, Geha, Raif, Irvine, Darrell J
Published 2020

Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8⁺ T cells

by Palmer, Megan Joan, Mahajan, Vinay S., Chen, Jianzhu, Irvine, Darrell J, Lauffenburger, Douglas A
Published 2012

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

by Metallo, Christian M., Gameiro, Paulo A., Bell, Eric L., Yang, Juanjuan, Hiller, Karsten, Jewell, Christopher M., Vander Heiden, Matthew G., Iliopoulos, Othon, Stephanopoulos, Gregory, Kelleher, Joanne Keene, Mattaini, Katherine Ruth, Guarente, Leonard Pershing, Johnson, Zachary, Irvine, Darrell J
Published 2014

Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity

by Zhang, Yuan, Li, Na, Suh, Heikyung, Irvine, Darrell J
Published 2018