Mycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 production.

by Dee N Dao, Kari Sweeney, Tsungda Hsu, Sudagar S Gurcha, Ivan P Nascimento, Ivan P Nascimento, Dan Roshevsky, Gurdyal S Besra, John Chan, Steven A Porcelli, William R Jacobs
Published 2008-06-01

Transcriptional regulation of multi-drug tolerance and antibiotic-induced responses by the histone-like protein Lsr2 in M. tuberculosis.

by Roberto Colangeli, Danica Helb, Catherine Vilchèze, Manzour Hernando Hazbón, Chee-Gun Lee, Hassan Safi, Brendan Sayers, Irene Sardone, Marcus B Jones, Robert D Fleischmann, Scott N Peterson, William R Jacobs, David Alland
Published 2007-06-01

Mycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cells.

by Kamalakannan Velmurugan, Bing Chen, Jessica L Miller, Sharon Azogue, Serdar Gurses, Tsungda Hsu, Michael Glickman, William R Jacobs, Steven A Porcelli, Volker Briken
Published 2007-07-01

An anaerobic-type alpha-ketoglutarate ferredoxin oxidoreductase completes the oxidative tricarboxylic acid cycle of Mycobacterium tuberculosis.

by Anthony D Baughn, Scott J Garforth, Catherine Vilchèze, William R Jacobs
Published 2009-11-01

A critical role for CD8 T cells in a nonhuman primate model of tuberculosis.

by Crystal Y Chen, Dan Huang, Richard C Wang, Ling Shen, Gucheng Zeng, Shuyun Yao, Yun Shen, Lisa Halliday, Jeff Fortman, Milton McAllister, Jim Estep, Robert Hunt, Daphne Vasconcelos, George Du, Steven A Porcelli, Michelle H Larsen, William R Jacobs, Barton F Haynes, Norman L Letvin, Zheng W Chen
Published 2009-04-01

Lysine auxotrophy combined with deletion of the SecA2 gene results in a safe and highly immunogenic candidate live attenuated vaccine for tuberculosis.

by Joseph Hinchey, Bo Y Jeon, Holly Alley, Bing Chen, Michael Goldberg, Steven Derrick, Sheldon Morris, William R Jacobs, Steven A Porcelli, Sunhee Lee
Published 2011-01-01

B cells regulate neutrophilia during Mycobacterium tuberculosis infection and BCG vaccination by modulating the interleukin-17 response.

by Lee Kozakiewicz, Yong Chen, Jiayong Xu, Yanhua Wang, Kyri Dunussi-Joannopoulos, Qinglin Ou, Joanne L Flynn, Steven A Porcelli, William R Jacobs, John Chan
Published 2013-01-01

Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice.

by Jan Korte, Marina Alber, Carolina M Trujillo, Karl Syson, Hendrik Koliwer-Brandl, René Deenen, Karl Köhrer, Michael A DeJesus, Travis Hartman, William R Jacobs, Stephen Bornemann, Thomas R Ioerger, Sabine Ehrt, Rainer Kalscheuer
Published 2016-12-01

Fluoromycobacteriophages for rapid, specific, and sensitive antibiotic susceptibility testing of Mycobacterium tuberculosis.

by Mariana Piuri, William R Jacobs, Graham F Hatfull
Published 2009-01-01

Prime-boost with Mycobacterium smegmatis recombinant vaccine improves protection in mice infected with Mycobacterium tuberculosis.

by Ana Paula Junqueira-Kipnis, Fábio Muniz de Oliveira, Monalisa Martins Trentini, Sangeeta Tiwari, Bing Chen, Danilo Pires Resende, Bruna D S Silva, Mei Chen, Lydia Tesfa, William R Jacobs, André Kipnis
Published 2013-01-01

Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis.

by Katherine C Yam, Igor D'Angelo, Rainer Kalscheuer, Haizhong Zhu, Jian-Xin Wang, Victor Snieckus, Lan H Ly, Paul J Converse, William R Jacobs, Natalie Strynadka, Lindsay D Eltis
Published 2009-03-01

Phosphorylation of KasB regulates virulence and acid-fastness in Mycobacterium tuberculosis.

by Catherine Vilchèze, Virginie Molle, Séverine Carrère-Kremer, Jade Leiba, Lionel Mourey, Shubhada Shenai, Grégory Baronian, Joann Tufariello, Travis Hartman, Romain Veyron-Churlet, Xavier Trivelli, Sangeeta Tiwari, Brian Weinrick, David Alland, Yann Guérardel, William R Jacobs, Laurent Kremer
Published 2014-05-01

Mycobacterium tuberculosis universal stress protein Rv2623 interacts with the putative ATP binding cassette (ABC) transporter Rv1747 to regulate mycobacterial growth.

by Lisa N Glass, Ganduri Swapna, Sivagami Sundaram Chavadi, JoAnn M Tufariello, Kaixia Mi, Joshua E Drumm, TuKiet T Lam, Guofeng Zhu, Chenyang Zhan, Catherine Vilchéze, Jesus Arcos, Yong Chen, Lijun Bi, Simren Mehta, Steven A Porcelli, Steve C Almo, Syun-Ru Yeh, William R Jacobs, Jordi B Torrelles, John Chan
Published 2017-07-01

Succinate dehydrogenase is the regulator of respiration in Mycobacterium tuberculosis.

by Travis Hartman, Brian Weinrick, Catherine Vilchèze, Michael Berney, Joanne Tufariello, Gregory M Cook, William R Jacobs
Published 2014-11-01

Metabolic Network for the Biosynthesis of Intra- and Extracellular α-Glucans Required for Virulence of Mycobacterium tuberculosis.

by Hendrik Koliwer-Brandl, Karl Syson, Robert van de Weerd, Govind Chandra, Ben Appelmelk, Marina Alber, Thomas R Ioerger, William R Jacobs, Jeroen Geurtsen, Stephen Bornemann, Rainer Kalscheuer
Published 2016-08-01

Reduced virulence of an extensively drug-resistant outbreak strain of Mycobacterium tuberculosis in a murine model.

by Kristen L Jurcic Smith, Divey Saini, Svetoslav Bardarov, Michelle Larsen, Richard Frothingham, Neel R Gandhi, William R Jacobs, A Willem Sturm, Sunhee Lee
Published 2014-01-01

Phosphoantigen/IL2 expansion and differentiation of Vγ2Vδ2 T cells increase resistance to tuberculosis in nonhuman primates.

by Crystal Y Chen, Shuyu Yao, Dan Huang, Huiyong Wei, Helene Sicard, Gucheng Zeng, Hassan Jomaa, Michelle H Larsen, William R Jacobs, Richard Wang, Norman Letvin, Yun Shen, Liyou Qiu, Ling Shen, Zheng W Chen
Published 2013-08-01

Malaria infections do not compromise vaccine-induced immunity against tuberculosis in mice.

by Marcela Parra, Steven C Derrick, Amy Yang, Jinhua Tian, Kristopher Kolibab, Miranda Oakley, Liyanage P Perera, William R Jacobs, Sanjai Kumar, Sheldon L Morris
Published 2011-01-01

Cluster K mycobacteriophages: insights into the evolutionary origins of mycobacteriophage TM4.

by Welkin H Pope, Christina M Ferreira, Deborah Jacobs-Sera, Robert C Benjamin, Ariangela J Davis, Randall J DeJong, Sarah C R Elgin, Forrest R Guilfoile, Mark H Forsyth, Alexander D Harris, Samuel E Harvey, Lee E Hughes, Peter M Hynes, Arrykka S Jackson, Marilyn D Jalal, Elizabeth A MacMurray, Coreen M Manley, Molly J McDonough, Jordan L Mosier, Larissa J Osterbann, Hannah S Rabinowitz, Corwin N Rhyan, Daniel A Russell, Margaret S Saha, Christopher D Shaffer, Stephanie E Simon, Erika F Sims, Isabel G Tovar, Emilie G Weisser, John T Wertz, Kathleen A Weston-Hafer, Kurt E Williamson, Bo Zhang, Steven G Cresawn, Paras Jain, Mariana Piuri, William R Jacobs, Roger W Hendrix, Graham F Hatfull
Published 2011-01-01