A novel histone deacetylase inhibitor MPT0L184 dysregulates cell-cycle checkpoints and initiates unscheduled mitotic signaling

by Ting-Yu Chang, Kunal Nepali, Yi-Ying Chen, Yu-Chen S.H. Yang, Kai-Cheng Hsu, Yun Yen, Shiow-Lin Pan, Jing-Ping Liou, Sung-Bau Lee
Published 2021-06-01

Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression

by Jing-Wen Shih, Wei-Fan Chiang, Alexander T. H. Wu, Ming-Heng Wu, Ling-Yu Wang, Yen-Ling Yu, Yu-Wen Hung, Wen-Chang Wang, Cheng-Ying Chu, Chiu-Lien Hung, Chun A. Changou, Yun Yen, Hsing-Jien Kung
Published 2017-06-01

The single nucleotide variant at c.662A>G in human RRM2B is a loss‐of‐function mutation

by Yen‐Tzu Tseng, Shang‐Wei Li, Wei‐Chun HuangFu, Yun Yen, I‐Hsuan Liu
Published 2020-11-01

Welcome to Medical Sciences: A New Open Access Platform for Research on Basic Medicines

by Yun Yen
Published 2013-04-01

Using T‐cell repertoire profiles as predictor in a primary mucosal melanoma

by Che‐Mai Chang, Yu‐Ming Liao, Gong‐Yau Lan, Wei‐Chiao Chang, Yun Yen
Published 2020-08-01

Correction to: Development and clinical applications of cancer immunotherapy against PD-1 signaling pathway

by Grace Wakabayashi, Yu-Ching Lee, Frank Luh, Chun-Nan Kuo, Wei-Chiao Chang, Yun Yen
Published 2019-12-01

Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells

by Chia-Lin Chen, Sheng-Chieh Hsu, Tan-Ya Chung, Cheng-Ying Chu, Hung-Jung Wang, Pei-Wen Hsiao, Shauh-Der Yeh, David K. Ann, Yun Yen, Hsing-Jien Kung
Published 2021-04-01

Development and clinical applications of cancer immunotherapy against PD-1 signaling pathway

by Grace Wakabayashi, Yu-Ching Lee, Frank Luh, Chun-Nan Kuo, Wei-Chiao Chang, Yun Yen
Published 2019-12-01

Chicken-Derived Humanized Antibody Targeting a Novel Epitope F2pep of Fibroblast Growth Factor Receptor 2: Potential Cancer Therapeutic Agent

by Keng-Chang Tsai, Chao-Di Chang, Ming-Hui Cheng, Tsai-Yu Lin, Yan-Ni Lo, Tz-Wen Yang, Fu-Ling Chang, Chen-Wei Chiang, Yu-Ching Lee, Yun Yen
Published 2019-01-01

Rrm2b deletion causes mitochondrial metabolic defects in renal tubules

by Yi-Fan Chen, I-Hsuan Lin, Yu-Ru Guo, Wei-Jun Chiu, Mai-Szu Wu, Wei Jia, Yun Yen
Published 2019-09-01

Arginine Signaling and Cancer Metabolism

by Chia-Lin Chen, Sheng-Chieh Hsu, David K. Ann, Yun Yen, Hsing-Jien Kung
Published 2021-07-01

Host immune response to anti-cancer camptothecin conjugated cyclodextrin-based polymers

by Yi-Fan Chen, Yen-Hsin Wang, Cing-Syuan Lei, Chun A. Changou, Mark E. Davis, Yun Yen
Published 2019-10-01

RRM2B-Mediated Regulation of Mitochondrial Activity and Inflammation under Oxidative Stress

by Er-Chieh Cho, Mei-Ling Kuo, Jia-hui Cheng, Yu-Chi Cheng, Yi-Chen Hsieh, Yun-Ru Liu, Rong-Hong Hsieh, Yun Yen
Published 2015-01-01

The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes

by Yu-Chu Wang, Kung-Chao Chang, Bo-Wen Lin, Jenq-Chang Lee, Chien-Hsien Lai, Li-Jyuan Lin, Yun Yen, Chang-Shen Lin, Shiang-Jie Yang, Peng-Chan Lin, Chung-Ta Lee, Liang-Yi Hung
Published 2018-06-01

Targeting Autophagy by MPT0L145, a Highly Potent PIK3C3 Inhibitor, Provides Synergistic Interaction to Targeted or Chemotherapeutic Agents in Cancer Cells

by Chun-Han Chen, Tsung-Han Hsieh, Yu-Chen Lin, Yun-Ru Liu, Jing-Ping Liou, Yun Yen
Published 2019-09-01

Astragalus membranaceus–Derived Anti-Programmed Death-1 Monoclonal Antibodies with Immunomodulatory Therapeutic Effects against Tumors

by Fu-Ling Chang, Keng-Chang Tsai, Tsai-Yu Lin, Tz-Wen Yang, Yan-Ni Lo, Wang-Chuan Chen, Jui-Hsien Chang, Mei-Kuang Lu, Chun-Tang Chiou, Po-Hung Chen, Yun Yen, Shiow-Lin Pan, Yu-Ching Lee
Published 2020-01-01

A Novel Multi-Target Small Molecule, LCC-09, Inhibits Stemness and Therapy-Resistant Phenotypes of Glioblastoma Cells by Increasing miR-34a and Deregulating the DRD4/Akt/mTOR Signa...

by Ya-Ting Wen, Alexander TH Wu, Oluwaseun Adebayo Bamodu, Li Wei, Chien-Min Lin, Yun Yen, Tsu-Yi Chao, Debabrata Mukhopadhyay, Michael Hsiao, Hsu-Shan Huang
Published 2019-09-01

A predictive signature for oxaliplatin and 5-fluorouracil based chemotherapy in locally advanced gastric cancer

by Qinchuan Wang, Xiyong Liu, Chen Chen, Jida Chen, Beisi Xu, Lini Chen, Jichun Zhou, Yasheng Huang, Wenjun Chen, Rongyue Teng, Wenhe Zhao, Lidan Jin, Jun Shen, Jianguo Shen, Yun Yen, Linbo Wang
Published 2021-01-01

Upregulation of Protein Synthesis and Proteasome Degradation Confers Sensitivity to Proteasome Inhibitor Bortezomib in Myc-Atypical Teratoid/Rhabdoid Tumors

by Huy Minh Tran, Kuo-Sheng Wu, Shian-Ying Sung, Chun Austin Changou, Tsung-Han Hsieh, Yun-Ru Liu, Yen-Lin Liu, Min-Lan Tsai, Hsin-Lun Lee, Kevin Li-Chun Hsieh, Wen-Chang Huang, Muh-Lii Liang, Hsin-Hung Chen, Yi-Yen Lee, Shih-Chieh Lin, Donald Ming-Tak Ho, Feng-Chi Chang, Meng-En Chao, Wan Chen, Shing-Shung Chu, Alice L. Yu, Yun Yen, Che-Chang Chang, Tai-Tong Wong
Published 2020-03-01

High-Grade B-Cell Lymphoma (HGBL) with <i>MYC</i> and <i>BCL2</i> and/or <i>BCL6</i> Rearrangements Is Predominantly BCL6-Rearranged and BCL6-Expressing in Taiwan

by Cheng-Chih Tsai, Yung-Cheng Su, Oluwaseun Adebayo Bamodu, Bo-Jung Chen, Wen-Chiuan Tsai, Wei-Hong Cheng, Chii-Hong Lee, Shu-Min Hsieh, Mei-Ling Liu, Chia-Lang Fang, Huan-Tze Lin, Chi-Long Chen, Chi-Tai Yeh, Wei-Hwa Lee, Ching-Liang Ho, Shiue-Wei Lai, Huey-En Tzeng, Yao-Yu Hsieh, Chia-Lun Chang, Yu-Mei Zheng, Hui-Wen Liu, Yun Yen, Jacqueline Whang-Peng, Tsu-Yi Chao
Published 2021-03-01