Synergistic toxicity in an in vivo model of neurodegeneration through the co-expression of human TDP-43M337V and tauT175D protein

by Alexander J. Moszczynski, Madeline Harvey, Niveen Fulcher, Cleusa de Oliveira, Patrick McCunn, Neil Donison, Robert Bartha, Susanne Schmid, Michael J. Strong, Kathryn Volkening
Published 2019-11-01

Pediatric methylation class HGNET-MN1: unresolved issues with terminology and grading

by Arnault Tauziède-Espariat, Mélanie Pagès, Alexandre Roux, Aurore Siegfried, Emmanuelle Uro-Coste, Yvan Nicaise, Annick Sevely, Marion Gambart, Sergio Boetto, Martin Dupuy, Pomone Richard, Romain Perbet, Matthieu Vinchon, Sabine Caron, Felipe Andreiuolo, Albane Gareton, Emmanuèle Lechapt, Fabrice Chrétien, Stéphanie Puget, Jacques Grill, Nathalie Boddaert, Pascale Varlet, on behalf of the RENOCLIP-LOC
Published 2019-11-01

Autism-linked mutations of CTTNBP2 reduce social interaction and impair dendritic spine formation via diverse mechanisms

by Pu-Yun Shih, Bing-Yuan Hsieh, Ching-Yen Tsai, Chiu-An Lo, Brian E. Chen, Yi-Ping Hsueh
Published 2020-11-01

Region-specific interneuron demyelination and heightened anxiety-like behavior induced by adolescent binge alcohol treatment

by James Rice, Laurence Coutellier, Jeffrey L. Weiner, Chen Gu
Published 2019-11-01

The EP300:BCOR fusion extends the genetic alteration spectrum defining the new tumoral entity of “CNS tumors with BCOR internal tandem duplication”

by Arnault Tauziède-Espariat, Gaëlle Pierron, Aurore Siegfried, Delphine Guillemot, Emmanuelle Uro-Coste, Yvan Nicaise, David Castel, Isabelle Catalaa, Delphine Larrieu-Ciron, Patrick Chaynes, Amaury de Barros, Julien Nicolau, Albane Gareton, Emmanuèle Lechapt, Fabrice Chrétien, Franck Bourdeaut, François Doz, Yassine Bouchoucha, Jacques Grill, Kévin Beccaria, Nathalie Boddaert, Raphaël Saffroy, Mélanie Pagès, Pascale Varlet
Published 2020-11-01

Multiplex proteomics identifies novel CSF and plasma biomarkers of early Alzheimer’s disease

by Christopher D. Whelan, Niklas Mattsson, Michael W. Nagle, Swetha Vijayaraghavan, Craig Hyde, Shorena Janelidze, Erik Stomrud, Julie Lee, Lori Fitz, Tarek A. Samad, Gayathri Ramaswamy, Richard A. Margolin, Anders Malarstig, Oskar Hansson
Published 2019-11-01

In vivo detection of tau fibrils and amyloid β aggregates with luminescent conjugated oligothiophenes and multiphoton microscopy

by Maria Calvo-Rodriguez, Steven S. Hou, Austin C. Snyder, Simon Dujardin, Hamid Shirani, K. Peter R. Nilsson, Brian J. Bacskai
Published 2019-11-01

EZHIP is a specific diagnostic biomarker for posterior fossa ependymomas, group PFA and diffuse midline gliomas H3-WT with EZHIP overexpression

by C. Antin, A. Tauziède-Espariat, M.-A. Debily, D. Castel, J. Grill, M. Pagès, O. Ayrault, F. Chrétien, A. Gareton, F. Andreiuolo, E. Lechapt, P. Varlet
Published 2020-11-01

Cell-free DNA and circulating TERT promoter mutation for disease monitoring in newly-diagnosed glioblastoma

by Maxime Fontanilles, Florent Marguet, Ludivine Beaussire, Nicolas Magne, Louis-Ferdinand Pépin, Cristina Alexandru, Isabelle Tennevet, Chantal Hanzen, Olivier Langlois, Fabrice Jardin, Annie Laquerrière, Nasrin Sarafan-Vasseur, Fréderic Di Fiore, Florian Clatot
Published 2020-11-01

Characterizing temporal genomic heterogeneity in pediatric low-grade gliomas

by Margot A. Lazow, Lindsey Hoffman, Austin Schafer, Diana S. Osorio, Daniel R. Boué, Sarah Rush, Erin Wright, Adam Lane, Mariko D. DeWire-Schottmiller, Teresa Smolarek, Jared Sipple, Heather Taggert, Jaime Reuss, Ralph Salloum, Trent R. Hummel, Peter de Blank, Natasha Pillay-Smiley, Mary E. Sutton, Anthony Asher, Charles B. Stevenson, Rachid Drissi, Jonathan L. Finlay, Maryam Fouladi, Christine Fuller
Published 2020-11-01

Microglial motility in Alzheimer’s disease and after Aβ42 immunotherapy: a human post-mortem study

by Diana K. Franco-Bocanegra, Bethany George, Laurie C. Lau, Clive Holmes, James A. R. Nicoll, Delphine Boche
Published 2019-11-01

Cerebral amyloid angiopathy aggravates perivascular clearance impairment in an Alzheimer’s disease mouse model

by Shin Heun Kim, Ji Hoon Ahn, Hyunwoo Yang, Peter Lee, Gou Young Koh, Yong Jeong
Published 2020-11-01

Phosphorylated TDP-43 aggregates in skeletal and cardiac muscle are a marker of myogenic degeneration in amyotrophic lateral sclerosis and various conditions

by Fumiaki Mori, Mari Tada, Tomoya Kon, Yasuo Miki, Kunikazu Tanji, Hidekachi Kurotaki, Masahiko Tomiyama, Tomohiko Ishihara, Osamu Onodera, Akiyoshi Kakita, Koichi Wakabayashi
Published 2019-10-01

Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities

by Annekathrin Reinhardt, Damian Stichel, Daniel Schrimpf, Christian Koelsche, Annika K. Wefers, Azadeh Ebrahimi, Philipp Sievers, Kristin Huang, M. Belén Casalini, Francisco Fernández-Klett, Abigail Suwala, Michael Weller, Dorothee Gramatzki, Joerg Felsberg, Guido Reifenberger, Albert Becker, Volkmar H. Hans, Marco Prinz, Ori Staszewski, Till Acker, Hildegard Dohmen, Christian Hartmann, Werner Paulus, Katharina Heß, Benjamin Brokinkel, Jens Schittenhelm, Rolf Buslei, Martina Deckert, Christian Mawrin, Ekkehard Hewer, Ute Pohl, Zane Jaunmuktane, Sebastian Brandner, Andreas Unterberg, Daniel Hänggi, Michael Platten, Stefan M. Pfister, Wolfgang Wick, Christel Herold-Mende, Andrey Korshunov, David E. Reuss, Felix Sahm, David T. W. Jones, David Capper, Andreas von Deimling
Published 2019-10-01

Alzheimer’s disease tau is a prominent pathology in LRRK2 Parkinson’s disease

by Michael X. Henderson, Medha Sengupta, John Q. Trojanowski, Virginia M. Y. Lee
Published 2019-11-01

Improved risk-stratification for posterior fossa ependymoma of childhood considering clinical, histological and genetic features – a retrospective analysis of the HIT ependymoma tr...

by Stephanie T. Jünger, Martin Mynarek, Inken Wohlers, Evelyn Dörner, Anja zur Mühlen, Natalia Velez-Char, Katja von Hoff, Stefan Rutkowski, Monika Warmuth-Metz, Rolf-Dieter Kortmann, Beate Timmermann, Sven Rahmann, Ludger Klein-Hitpass, Andre O. von Bueren, Torsten Pietsch
Published 2019-11-01

Carriership of two copies of C9orf72 hexanucleotide repeat intermediate-length alleles is a risk factor for ALS in the Finnish population

by Karri Kaivola, Samuli J. Salmi, Lilja Jansson, Jyrki Launes, Laura Hokkanen, Anna-Kaisa Niemi, Kari Majamaa, Jari Lahti, Johan G. Eriksson, Timo Strandberg, Hannu Laaksovirta, Pentti J. Tienari
Published 2020-11-01

Meningomyeloencephalitis secondary to Mycobacterium haemophilum infection in AIDS

by Sandra Leskinen, Xena Flowers, Katharina Thoene, Anne-Catrin Uhlemann, James E. Goldman, Richard A. Hickman
Published 2020-05-01

Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations

by Meixiang Huang, Erica Modeste, Eric Dammer, Paola Merino, Georgia Taylor, Duc M. Duong, Qiudong Deng, Christopher J. Holler, Marla Gearing, Dennis Dickson, Nicholas T. Seyfried, Thomas Kukar
Published 2020-10-01

Alzheimer’s disease neuropathological change and loss of matrix/neuropil in patients with idiopathic Normal Pressure Hydrocephalus, a model of Alzheimer’s disease

by Sylwia Libard, Irina Alafuzoff
Published 2019-05-01