Genetic epidemiology single nucleotide polymorphism 2 Application fields 1 Architecture 1 Article 1 Benchmarking 1 Biased samples 1 Biological mechanisms 1 Case–control study 1 Genetic variants 1 Gene–environment interaction 1 Genome-Wide Association Study 1 Genome-wide association studies 1 High dimensional data 1 Lasso Penalization 1 Least squares approximations 1 Least-Squares Analysis 1 Meta-analysis 1 Oncology 1 Partial Least Square 1 Partial least square (PLS) 1 Pathway analysis 1 Penalized partial least squares 1 Phenotype 1 Pleiotropic effects 1 Pleiotropy 1 Polymorphism, Single Nucleotide 1 Priori information 1 Semiparametric estimation 1 Signal detection 1