Product-Related Impurities in Clinical-Grade Recombinant AAV Vectors: Characterization and Risk Assessment

by J. Fraser Wright
Published 2014-03-01

Innate immune responses to AAV vectors

by Geoffrey L Rogers, Ashley T Martino, George V Aslanidi, Giridhara R Jayandharan, Arun eSrivastava, Roland W. Herzog
Published 2011-09-01

Efficient gene delivery and selective transduction of astrocytes in the mammalian brain using viral vectors

by Nicolas eMerienne, Juliette eLe Douce, Emilie eFaivre, Nicole eDéglon, Gilles eBonvento
Published 2013-07-01

Adeno-associated viral vector delivered RNAi for gene therapy of SOD1 Amyotrophic Lateral Sclerosis

by Lorelei Stoica, Lorelei Stoica, Miguel Sena-Esteves, Miguel Sena-Esteves
Published 2016-08-01

Human Immune Responses to Adeno-Associated Virus (AAV) Vectors

by Giuseppe Ronzitti, David-Alexandre Gross, Federico Mingozzi
Published 2020-04-01

DNA Minicircle Technology Improves Purity of Adeno-associated Viral Vector Preparations

by Maria Schnödt, Marco Schmeer, Barbara Kracher, Christa Krüsemann, Laura Escalona Espinosa, Anja Grünert, Thomas Fuchsluger, Anja Rischmüller, Martin Schleef, Hildegard Büning
Published 2016-01-01

Cell-mediated Immunity to AAV vectors, evolving concepts and potential solutions

by Etiena eBasner-Tschakarjan, Federico eMingozzi
Published 2014-07-01

Enhanced Transduction of Human Hematopoietic Stem Cells by AAV6 Vectors: Implications in Gene Therapy and Genome Editing

by Hua Yang, Keyun Qing, Geoffrey D. Keeler, Ling Yin, Mario Mietzsch, Chen Ling, Brad E. Hoffman, Mavis Agbandje-McKenna, Mengqun Tan, Wei Wang, Arun Srivastava
Published 2020-06-01

Gene Editing for the Efficient Correction of a Recurrent COL7A1 Mutation in Recessive Dystrophic Epidermolysis Bullosa Keratinocytes

by Cristina Chamorro, Angeles Mencía, David Almarza, Blanca Duarte, Hildegard Büning, Jessica Sallach, Ingrid Hausser, Marcela Del Río, Fernando Larcher, Rodolfo Murillas
Published 2016-01-01

Mapping the AAV capsid host antibody response towards the development of second generation gene delivery vectors

by Yu-Shan eTseng, Mavis eAgbandje-Mckenna
Published 2014-01-01

Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-β and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells

by Stephanie Morscheid, Ana Rey-Rico, Gertrud Schmitt, Henning Madry, Magali Cucchiarini, Jagadeesh Kumar Venkatesan
Published 2019-05-01

The development of a viral mediated CRISPR/Cas9 system with doxycycline dependent gRNA expression for inducible in vitro and in vivo genome editing.

by Christopher A. de Solis, Anthony Ho, Roopashri Holehonnur, Jonathan Eric Ploski
Published 2016-08-01

Improved immunological tolerance following combination therapy with CTLA-4/Ig and AAV-mediated PD-L1/2 muscle gene transfer

by Sahil eAdriouch, Sahil eAdriouch, Emilie eFranck, Emilie eFranck, Laurent eDrouot, Laurent eDrouot, Carole eBonneau, Nelly eJolinon, Anna eSalvetti, Olivier eBoyer, Olivier eBoyer, Olivier eBoyer
Published 2011-09-01

Systemic gene delivery to the central nervous system using Adeno-associated virus

by Mathieu eBOURDENX, Mathieu eBOURDENX, Nathalie eDUTHEIL, Nathalie eDUTHEIL, Erwan eBEZARD, Erwan eBEZARD, Benjamin eDEHAY, Benjamin eDEHAY
Published 2014-06-01

CHIP, a carboxy terminus HSP-70 interacting protein, prevents cell death induced by endoplasmic reticulum stress in the central nervous system

by Felipe eCabral Miranda, Juliana eAdão-Novaes, William eHauswirth, Rafael eLinden, Hilda ePetrs Silva, Luciana Barreto Chiarini
Published 2015-01-01

The intersection of vector biology, gene therapy, and hemophilia

by Leszek Lisowski, Janice M. Staber, J. Fraser Wright, Leonard A. Valentino
Published 2021-08-01

Controlled Release of rAAV Vectors from APMA-Functionalized Contact Lenses for Corneal Gene Therapy

by Fernando Alvarez-Rivera, Ana Rey-Rico, Jagadeesh K Venkatesan, Luis Diaz-Gomez, Magali Cucchiarini, Angel Concheiro, Carmen Alvarez-Lorenzo
Published 2020-04-01

Remodeling of Human Osteochondral Defects via rAAV-Mediated Co-Overexpression of TGF-β and IGF-I from Implanted Human Bone Marrow-Derived Mesenchymal Stromal Cells

by Stephanie Morscheid, Jagadeesh Kumar Venkatesan, Ana Rey-Rico, Gertrud Schmitt, Magali Cucchiarini
Published 2019-08-01

Elevated expression of serotonin 5-HT2A receptors in the rat ventral tegmental area enhances vulnerability to the behavioral effects of cocaine

by David V. Herin, David V. Herin, Marcy J. Bubar, Marcy J. Bubar, Patricia K. Seitz, Patricia K. Seitz, Mary L. Thomas, Mary L. Thomas, Gilbert R. Hillman, Gilbert R. Hillman, Yevgeniya I. Tarasenko, Yevgeniya I. Tarasenko, Ping eWu, Ping eWu, Kathryn A. Cunningham, Kathryn A. Cunningham
Published 2013-02-01

AAV VECTORS VACCINES AGAINST INFECTIOUS DISEASES

by Karen eNieto, Anna eSalvetti
Published 2014-01-01