Target‐Mediated Drug Disposition Model for Bispecific Antibodies: Properties, Approximation, and Optimal Dosing Strategy

by Johannes Schropp, Antari Khot, Dhaval K. Shah, Gilbert Koch
Published 2019-03-01

Quantitative Systems Pharmacology Models for a New International Cardiac Safety Regulatory Paradigm: An Overview of the Comprehensive In Vitro Proarrhythmia Assay In Silico Modelin...

by Zhihua Li, Christine Garnett, David G. Strauss
Published 2019-06-01

Estimation of an Appropriate Dose of Trazodone for Pediatric Insomnia and the Potential for a Trazodone–Atomoxetine Interaction

by Laura Oggianu, Alice B. Ke, Manoranjenni Chetty, Rossella Picollo, Vanessa Petrucci, Fabrizio Calisti, Fabio Garofolo, Serena Tongiani
Published 2020-02-01

Erratum: Pharmacokinetics of Sulfadoxine and Pyrimethamine for Intermittent Preventive Treatment of Malaria During Pregnancy and After Delivery

by M. deKock, J. Tarning, L. Workman, M. M. Nyunt, I. Adam, K. I. Barnes, P. Denti
Published 2020-04-01

Tisagenlecleucel Model‐Based Cellular Kinetic Analysis of Chimeric Antigen Receptor–T Cells

by Andrew M. Stein, Stephan A. Grupp, John E. Levine, Theodore W. Laetsch, Michael A. Pulsipher, Michael W. Boyer, Keith J. August, Bruce L. Levine, Lori Tomassian, Sweta Shah, Mimi Leung, Pai‐Hsi Huang, Rakesh Awasthi, Karen Thudium Mueller, Patricia A. Wood, Carl H. June
Published 2019-05-01

Population Pharmacokinetics of Ipilimumab in Combination With Nivolumab in Patients With Advanced Solid Tumors

by Kinjal Sanghavi, Jason Zhang, Xiaochen Zhao, Yan Feng, Paul Statkevich, Jennifer Sheng, Amit Roy, Heather E. Vezina
Published 2020-01-01

The Virtual Anemia Trial: An Assessment of Model‐Based In Silico Clinical Trials of Anemia Treatment Algorithms in Patients With Hemodialysis

by Doris H. Fuertinger, Alice Topping, Franz Kappel, Stephan Thijssen, Peter Kotanko
Published 2018-04-01

Bayesian Data Assimilation to Support Informed Decision Making in Individualized Chemotherapy

by Corinna Maier, Niklas Hartung, Jana deWiljes, Charlotte Kloft, Wilhelm Huisinga
Published 2020-03-01

Data Digitizing: Accurate and Precise Data Extraction for Quantitative Systems Pharmacology and Physiologically‐Based Pharmacokinetic Modeling

by Jan‐Georg Wojtyniak, Hannah Britz, Dominik Selzer, Matthias Schwab, Thorsten Lehr
Published 2020-06-01

Industrialization of Quantitative Systems Pharmacology

by Brian Topp, Maria E. Trujillo, Vikram Sinha
Published 2019-06-01

A Flexible Approach for Context‐Dependent Assessment of Quantitative Systems Pharmacology Models

by Saroja Ramanujan, Jason R. Chan, Christina M. Friedrich, Craig J. Thalhauser
Published 2019-06-01

Causa Nostra: The Potentially Legitimate Business of Drawing Causal Inferences From Observational Data

by James A. Rogers
Published 2019-05-01

Population Pharmacodynamic Modeling of Epoetin Alfa in End‐Stage Renal Disease Patients Receiving Maintenance Treatment Using Bayesian Approach

by Ly Minh Nguyen, Calvin J. Meaney, Gauri G. Rao, Mandip Panesar, Wojciech Krzyzanski
Published 2020-10-01

A Minimal Physiologically‐Based Pharmacokinetic Model for Tacrolimus in Living‐Donor Liver Transplantation: Perspectives Related to Liver Regeneration and the cytochrome P450 3A5 (...

by Kotaro Itohara, Ikuko Yano, Tetsunori Tsuzuki, Miwa Uesugi, Shunsaku Nakagawa, Atsushi Yonezawa, Hideaki Okajima, Toshimi Kaido, Shinji Uemoto, Kazuo Matsubara
Published 2019-08-01

Initiation of Antiviral Treatment in SARS‐CoV2: Modeling Viral Dynamics and Drug Properties

by Daniel Scholes Rosenbloom, Ping Zhao, Vikram Sinha
Published 2020-09-01

Recommendations for the Design of Clinical Drug–Drug Interaction Studies With Itraconazole Using a Mechanistic Physiologically‐Based Pharmacokinetic Model

by Yuan Chen, Tamara D. Cabalu, Ernesto Callegari, Heidi Einolf, Lichuan Liu, Neil Parrott, Sheila Annie Peters, Edgar Schuck, Pradeep Sharma, Helen Tracey, Vijay V. Upreti, Ming Zheng, Andy Z.X. Zhu, Stephen D. Hall
Published 2019-09-01

Physiologically‐Based Pharmacokinetic Modeling of Atorvastatin Incorporating Delayed Gastric Emptying and Acid‐to‐Lactone Conversion

by Bridget L. Morse, Jeffrey J. Alberts, Maria M. Posada, Jessica Rehmel, Anil Kolur, Lai San Tham, Corina Loghin, Kathleen M. Hillgren, Stephen D. Hall, Gemma L. Dickinson
Published 2019-09-01

Physiologically‐Based Pharmacokinetic Modeling for Predicting Drug Interactions of a Combination of Olanzapine and Samidorphan

by Lei Sun, Lisa vonMoltke, Karen Rowland Yeo
Published 2020-02-01

Consideration of a Credibility Assessment Framework in Model‐Informed Drug Development: Potential Application to Physiologically‐Based Pharmacokinetic Modeling and Simulation

by Colleen Kuemmel, Yuching Yang, Xinyuan Zhang, Jeffry Florian, Hao Zhu, Million Tegenge, Shiew‐Mei Huang, Yaning Wang, Tina Morrison, Issam Zineh
Published 2020-01-01

Verifying and Validating Quantitative Systems Pharmacology and In Silico Models in Drug Development: Current Needs, Gaps, and Challenges

by Flora T. Musuamba, Roberta Bursi, Efthymios Manolis, Kristin Karlsson, Alexander Kulesza, Eulalie Courcelles, Jean‐Pierre Boissel, Raphaëlle Lesage, Cécile Crozatier, Emmanuelle M. Voisin, Cécile F. Rousseau, Thierry Marchal, Rossana Alessandrello, Liesbet Geris
Published 2020-04-01