Expanding the Therapeutic Window for CAR T Cell Therapy in Solid Tumors: The Knowns and Unknowns of CAR T Cell Biology

by Keisuke Watanabe, Shunichiro Kuramitsu, Avery D. Posey, Avery D. Posey, Avery D. Posey, Carl H. June, Carl H. June, Carl H. June
Published 2018-10-01

Cancer immunotherapy comes of age and looks for maturity

by Amanda Finck, Saar I. Gill, Carl H. June
Published 2020-07-01

Engineered T Cell Therapies from a Drug Development Viewpoint

by Fang Chen, Joseph A. Fraietta, Carl H. June, Zhongwei Xu, J. Joseph Melenhorst, Simon F. Lacey
Published 2019-02-01

Bispecific Antibody Armed Metabolically Enhanced Headless CAR T Cells

by Archana Thakur, John Scholler, Ewa Kubicka, Edwin T. Bliemeister, Dana L. Schalk, Carl H. June, Lawrence G. Lum
Published 2021-07-01

Novel T cells with improved in vivo anti-tumor activity generated by RNA electroporation

by Xiaojun Liu, Shuguang Jiang, Chongyun Fang, Hua Li, Xuhua Zhang, Fuqin Zhang, Carl H. June, Yangbing Zhao
Published 2017-05-01

Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18

by Biliang Hu, Jiangtao Ren, Yanping Luo, Brian Keith, Regina M. Young, John Scholler, Yangbing Zhao, Carl H. June
Published 2017-09-01

iGUIDE: an improved pipeline for analyzing CRISPR cleavage specificity

by Christopher L. Nobles, Shantan Reddy, January Salas-McKee, Xiaojun Liu, Carl H. June, J. Joseph Melenhorst, Megan M. Davis, Yangbing Zhao, Frederic D. Bushman
Published 2019-01-01

Distinct effects of IL-18 on the engraftment and function of human effector CD8 T cells and regulatory T cells.

by Richard G Carroll, Carmine Carpenito, Xiaochuan Shan, Gwenn Danet-Desnoyers, Ronghua Liu, Shuguang Jiang, Steven M Albelda, Tatiana Golovina, George Coukos, James L Riley, Zdenka L Jonak, Carl H June
Published 2008-09-01

Single-cell multiomics dissection of basal and antigen-specific activation states of CD19-targeted CAR T cells

by Carl H June, David M Barrett, Stephan A Grupp, Rong Fan, Marcela V Maus, Zhiliang Bai, Stefan Lundh, Dongjoo Kim, Steven Woodhouse, Regina M Myers, Pablo G Camara, J Joseph Melenhorst
Published 2021-05-01

Human CD26high T cells elicit tumor immunity against multiple malignancies via enhanced migration and persistence

by Stefanie R. Bailey, Michelle H. Nelson, Kinga Majchrzak, Jacob S. Bowers, Megan M. Wyatt, Aubrey S. Smith, Lillian R. Neal, Keisuke Shirai, Carmine Carpenito, Carl H. June, Michael J. Zilliox, Chrystal M. Paulos
Published 2017-12-01

Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1.

by Shoba Amarnath, Carliann M Costanzo, Jacopo Mariotti, Jessica L Ullman, William G Telford, Veena Kapoor, James L Riley, Bruce L Levine, Carl H June, Timothy Fong, Noel L Warner, Daniel H Fowler
Published 2010-02-01

Case Report: Prolonged Survival Following EGFRvIII CAR T Cell Treatment for Recurrent Glioblastoma

by Joseph S. Durgin, Joseph S. Durgin, Joseph S. Durgin, Fraser Henderson, MacLean P. Nasrallah, MacLean P. Nasrallah, Suyash Mohan, Sumei Wang, Simon F. Lacey, Jan Joseph Melenhorst, Jan Joseph Melenhorst, Jan Joseph Melenhorst, Arati S. Desai, Arati S. Desai, John Y. K. Lee, Marcela V. Maus, Carl H. June, Carl H. June, Steven Brem, Steven Brem, Roddy S. O’Connor, Roddy S. O’Connor, Zev Binder, Zev Binder, Donald M. O’Rourke, Donald M. O’Rourke
Published 2021-05-01

Chimeric antigen receptor (CAR) T therapies for the treatment of hematologic malignancies: clinical perspective and significance

by Michael M. Boyiadzis, Madhav V. Dhodapkar, Renier J. Brentjens, James N. Kochenderfer, Sattva S. Neelapu, Marcela V. Maus, David L. Porter, David G. Maloney, Stephan A. Grupp, Crystal L. Mackall, Carl H. June, Michael R. Bishop
Published 2018-12-01

CAR T-Cells Depend on the Coupling of NADH Oxidation with ATP Production

by Juan C. Garcia-Canaveras, David Heo, Sophie Trefely, John Leferovich, Chong Xu, Benjamin I. Philipson, Saba Ghassemi, Michael C. Milone, Edmund K. Moon, Nathaniel W. Snyder, Carl H. June, Joshua D. Rabinowitz, Roddy S. O’Connor
Published 2021-09-01

Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design

by Saba Ghassemi, Francisco J. Martinez-Becerra, Alyssa M. Master, Sarah A. Richman, David Heo, John Leferovich, Yitao Tu, Juan Carlos García-Cañaveras, Asma Ayari, Yinan Lu, Ai Wang, Joshua D. Rabinowitz, Michael C. Milone, Carl H. June, Roddy S. O’Connor
Published 2020-09-01

Tisagenlecleucel Model‐Based Cellular Kinetic Analysis of Chimeric Antigen Receptor–T Cells

by Andrew M. Stein, Stephan A. Grupp, John E. Levine, Theodore W. Laetsch, Michael A. Pulsipher, Michael W. Boyer, Keith J. August, Bruce L. Levine, Lori Tomassian, Sweta Shah, Mimi Leung, Pai‐Hsi Huang, Rakesh Awasthi, Karen Thudium Mueller, Patricia A. Wood, Carl H. June
Published 2019-05-01

A Cure for HIV Infection: “Not in My Lifetime” or “Just Around the Corner”?

by Michael M. Lederman, Paula M. Cannon, Judith S. Currier, Carl H. June, Hans-Peter Kiem, Daniel R. Kuritzkes, Sharon R. Lewin, David M. Margolis, Joseph M. McCune, John W. Mellors, Timothy W. Schacker, Rafick P. Sekaly, Pablo Tebas, Bruce D. Walker, Daniel C. Douek
Published 2016-08-01

Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus.

by George J Leslie, Jianbin Wang, Max W Richardson, Beth S Haggarty, Kevin L Hua, Jennifer Duong, Anthony J Secreto, Andrea P O Jordon, Josephine Romano, Kritika E Kumar, Joshua J DeClercq, Philip D Gregory, Carl H June, Michael J Root, James L Riley, Michael C Holmes, James A Hoxie
Published 2016-11-01

Checkpoint Blockade Reverses Anergy in IL-13Rα2 Humanized scFv-Based CAR T Cells to Treat Murine and Canine Gliomas

by Yibo Yin, Alina C. Boesteanu, Zev A. Binder, Chong Xu, Reiss A. Reid, Jesse L. Rodriguez, Danielle R. Cook, Radhika Thokala, Kristin Blouch, Bevin McGettigan-Croce, Logan Zhang, Christoph Konradt, Alexandria P. Cogdill, M. Kazim Panjwani, Shuguang Jiang, Denis Migliorini, Nadia Dahmane, Avery D. Posey, Jr., Carl H. June, Nicola J. Mason, Zhiguo Lin, Donald M. O’Rourke, Laura A. Johnson
Published 2018-12-01

Pooled safety analysis of tisagenlecleucel in children and young adults with B cell acute lymphoblastic leukemia

by Rajen Mody, Carl H June, Michael R Verneris, Stephan A Grupp, Keith J August, André Baruchel, Shannon L Maude, Peter Bader, Stella M Davies, John E Levine, Michael A Pulsipher, Andrew C Dietz, Susana Rives, G Douglas Myers, Jochen Buechner, Theodore W Laetsch, Henrique Bittencourt, Michael W Boyer, Barbara De Moerloose, Muna Qayed, Christine L Phillips, Timothy A Driscoll, Krysta Schlis, Patricia A Wood, Lan Yi, Mimi Leung, Lamis K Eldjerou
Published 2021-08-01