Lead exposure is associated with functional and microstructural changes in the healthy human brain

by Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susum Yokota, Magistro Daniele, Yuko Sassa, Ryuta Kawashima
Published 2021-07-01

Butyrophilin-like 2 regulates site-specific adaptations of intestinal γδ intraepithelial lymphocytes

by Casandra Panea, Ruoyu Zhang, Jeffrey VanValkenburgh, Min Ni, Christina Adler, Yi Wei, Francisca Ochoa, Jennifer Schmahl, Yajun Tang, Chia-Jen Siao, William Poueymirou, Jennifer Espert, Wei Keat Lim, Gurinder S. Atwal, Andrew J. Murphy, Matthew A. Sleeman, Zaruhi Hovhannisyan, Sokol Haxhinasto
Published 2021-07-01

Complex population structure of the Atlantic puffin revealed by whole genome analyses

by Oliver Kersten, Bastiaan Star, Deborah M. Leigh, Tycho Anker-Nilssen, Hallvard Strøm, Jóhannis Danielsen, Sébastien Descamps, Kjell E. Erikstad, Michelle G. Fitzsimmons, Jérôme Fort, Erpur S. Hansen, Mike P. Harris, Martin Irestedt, Oddmund Kleven, Mark L. Mallory, Kjetill S. Jakobsen, Sanne Boessenkool
Published 2021-07-01

Preclinical validation of a live attenuated dermotropic Leishmania vaccine against vector transmitted fatal visceral leishmaniasis

by Subir Karmakar, Nevien Ismail, Fabiano Oliveira, James Oristian, Wen Wei Zhang, Swarnendu Kaviraj, Kamaleshwar P. Singh, Abhishek Mondal, Sushmita Das, Krishna Pandey, Parna Bhattacharya, Greta Volpedo, Sreenivas Gannavaram, Monika Satoskar, Sanika Satoskar, Rajiv M. Sastry, Timur Oljuskin, Telly Sepahpour, Claudio Meneses, Shinjiro Hamano, Pradeep Das, Greg Matlashewski, Sanjay Singh, Shaden Kamhawi, Ranadhir Dey, Jesus G. Valenzuela, Abhay Satoskar, Hira L. Nakhasi
Published 2021-07-01

PRL3 induces polypoid giant cancer cells eliminated by PRL3-zumab to reduce tumor relapse

by Min Thura, Zu Ye, Abdul Qader Al-Aidaroos, Qiancheng Xiong, Jun Yi Ong, Abhishek Gupta, Jie Li, Ke Guo, Koon Hwee Ang, Qi Zeng
Published 2021-07-01

Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection

by Thomas L. Williams, Maria T. Colzani, Robyn G. C. Macrae, Emma L. Robinson, Stuart Bloor, Edward J. D. Greenwood, Jun Ru Zhan, Gregory Strachan, Rhoda E. Kuc, Duuamene Nyimanu, Janet J. Maguire, Paul J. Lehner, Sanjay Sinha, Anthony P. Davenport
Published 2021-07-01

Blocking the GITR-GITRL pathway to overcome resistance to therapy in sarcomatoid malignant pleural mesothelioma

by Meilin Chan, Licun Wu, Zhihong Yun, Trevor D. McKee, Michael Cabanero, Yidan Zhao, Mikihiro Kohno, Junichi Murakami, Marc de Perrot
Published 2021-07-01

Cuticular hydrocarbons are associated with mating success and insecticide resistance in malaria vectors

by Kelsey L. Adams, Simon P. Sawadogo, Charles Nignan, Abdoulaye Niang, Douglas G. Paton, W. Robert Shaw, Adam South, Jennifer Wang, Maurice A. Itoe, Kristine Werling, Roch K. Dabiré, Abdoulaye Diabaté, Flaminia Catteruccia
Published 2021-07-01

Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations

by Chaojie Yang, Brian Hallmark, Jin Choul Chai, Timothy D. O’Connor, Lindsay M. Reynolds, Alexis C. Wood, Michael Seeds, Yii-Der Ida Chen, Lyn M. Steffen, Michael Y. Tsai, Robert C. Kaplan, Martha L. Daviglus, Lawrence J. Mandarino, Amanda M. Fretts, Rozenn N. Lemaitre, Dawn K. Coletta, Sarah A. Blomquist, Laurel M. Johnstone, Chandra Tontsch, Qibin Qi, Ingo Ruczinski, Stephen S. Rich, Rasika A. Mathias, Floyd H. Chilton, Ani Manichaikul
Published 2021-07-01

Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif

by Mark Ultsch, Michael J. Holliday, Stefan Gerhardy, Paul Moran, Suzie J. Scales, Nidhi Gupta, Francesca Oltrabella, Cecilia Chiu, Wayne Fairbrother, Charles Eigenbrot, Daniel Kirchhofer
Published 2021-07-01

Rational engineering of ratiometric calcium sensors with bright green and red fluorescent proteins

by Diming Zhang, Emily Redington, Yiyang Gong
Published 2021-07-01

MacroGreen, a simple tool for detection of ADP-ribosylated proteins

by Antonio Ginés García-Saura, Laura K. Herzog, Nico P. Dantuma, Herwig Schüler
Published 2021-07-01

FIP200 restricts RNA virus infection by facilitating RIG-I activation

by Lingyan Wang, Kun Song, Wenzhuo Hao, Yakun Wu, Girish Patil, Fang Hua, Yiwen Sun, Chaoqun Huang, Jerry Ritchey, Clinton Jones, Lin Liu, Jun-Lin Guan, Shitao Li
Published 2021-07-01

ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models

by Teresa Lambe, Alexandra J. Spencer, Kelly M. Thomas, Karen E. Gooch, Stephen Thomas, Andrew D. White, Holly E. Humphries, Daniel Wright, Sandra Belij-Rammerstorfer, Nazia Thakur, Carina Conceicao, Robert Watson, Leonie Alden, Lauren Allen, Marilyn Aram, Kevin R. Bewley, Emily Brunt, Phillip Brown, Breeze E. Cavell, Rebecca Cobb, Susan A. Fotheringham, Ciaran Gilbride, Debbie J. Harris, Catherine M. K. Ho, Laura Hunter, Chelsea L. Kennard, Stephanie Leung, Vanessa Lucas, Didier Ngabo, Kathryn A. Ryan, Hannah Sharpe, Charlotte Sarfas, Laura Sibley, Gillian S. Slack, Marta Ulaszewska, Nadina Wand, Nathan R. Wiblin, Fergus V. Gleeson, Dalan Bailey, Sally Sharpe, Sue Charlton, Francisco J. Salguero, Miles W. Carroll, Sarah C. Gilbert
Published 2021-07-01

Insights into rumen microbial biosynthetic gene cluster diversity through genome-resolved metagenomics

by Christopher L. Anderson, Samodha C. Fernando
Published 2021-06-01

Phylogenomics illuminates the evolution of bobtail and bottletail squid (order Sepiolida)

by Gustavo Sanchez, Fernando Á. Fernández-Álvarez, Morag Taite, Chikatoshi Sugimoto, Jeffrey Jolly, Oleg Simakov, Ferdinand Marlétaz, Louise Allcock, Daniel S. Rokhsar
Published 2021-06-01

Long-term field-realistic exposure to a next-generation pesticide, flupyradifurone, impairs honey bee behaviour and survival

by Simone Tosi, James C. Nieh, Annely Brandt, Monica Colli, Julie Fourrier, Herve Giffard, Javier Hernández-López, Valeria Malagnini, Geoffrey R. Williams, Noa Simon-Delso
Published 2021-06-01

Reinterpretation of purported molting evidence in the Thermopolis Archaeopteryx

by Yosef Kiat, Peter Pyle, Amir Balaban, Jingmai K. O’Connor
Published 2021-07-01

Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest Myzus persicae

by Kumar Saurabh Singh, Erick M. G. Cordeiro, Bartlomiej J. Troczka, Adam Pym, Joanna Mackisack, Thomas C. Mathers, Ana Duarte, Fabrice Legeai, Stéphanie Robin, Pablo Bielza, Hannah J. Burrack, Kamel Charaabi, Ian Denholm, Christian C. Figueroa, Richard H. ffrench-Constant, Georg Jander, John T. Margaritopoulos, Emanuele Mazzoni, Ralf Nauen, Claudio C. Ramírez, Guangwei Ren, Ilona Stepanyan, Paul A. Umina, Nina V. Voronova, John Vontas, Martin S. Williamson, Alex C. C. Wilson, Gao Xi-Wu, Young-Nam Youn, Christoph T. Zimmer, Jean-Christophe Simon, Alex Hayward, Chris Bass
Published 2021-07-01

Multiplexed imaging analysis of the tumor-immune microenvironment reveals predictors of outcome in triple-negative breast cancer

by Aalok Patwa, Rikiya Yamashita, Jin Long, Tyler Risom, Michael Angelo, Leeat Keren, Daniel L. Rubin
Published 2021-07-01