A mathematical model of the circadian clock and drug pharmacology to optimize irinotecan administration timing in colorectal cancer

by Janina Hesse, Julien Martinelli, Ouda Aboumanify, Annabelle Ballesta, Angela Relógio
Published 2021-01-01

Fast mutual exclusivity algorithm nominates potential synthetic lethal gene pairs through brute force matrix product computations

by Tarcisio Fedrizzi, Yari Ciani, Francesca Lorenzin, Thomas Cantore, Paola Gasperini, Francesca Demichelis
Published 2021-01-01

MetaCancer: A deep learning-based pan-cancer metastasis prediction model developed using multi-omics data

by Somayah Albaradei, Francesco Napolitano, Maha A. Thafar, Takashi Gojobori, Magbubah Essack, Xin Gao
Published 2021-01-01

Deciphering the mechanism of action of antitubercular compounds with metabolomics

by Isin T. Sakallioglu, Raúl G. Barletta, Patrick H. Dussault, Robert Powers
Published 2021-01-01

Magnesium ions regulate mesenchymal stem cells population and osteogenic differentiation: A fuzzy agent-based modeling approach

by Jalil Nourisa, Berit Zeller-Plumhoff, Heike Helmholz, Bérengère Luthringer-Feyerabend, Vladimir Ivannikov, Regine Willumeit-Römer
Published 2021-01-01

Survival analysis across the entire transcriptome identifies biomarkers with the highest prognostic power in breast cancer

by Balázs Győrffy
Published 2021-01-01

Identification of cyclin protein using gradient boost decision tree algorithm

by Hasan Zulfiqar, Shi-Shi Yuan, Qin-Lai Huang, Zi-Jie Sun, Fu-Ying Dao, Xiao-Long Yu, Hao Lin
Published 2021-01-01

Quantitative elucidation of associations between nucleotide identity and physicochemical properties of amino acids and the functional insight

by Yan-Ting Jin, Tian-Yue Jin, Zhi-Li Zhang, Yuan-Nong Ye, Zixin Deng, Ju Wang, Feng-Biao Guo
Published 2021-01-01

Nucleobindin-2 consists of two structural components: The Zn2+-sensitive N-terminal half, consisting of nesfatin-1 and -2, and the Ca2+-sensitive C-terminal half, consisting of nes...

by Dominika Bystranowska, Anna Skorupska, Katarzyna Sołtys, Michał Padjasek, Artur Krężel, Andrzej Żak, Magdalena Kaus-Drobek, Michał Taube, Maciej Kozak, Andrzej Ożyhar
Published 2021-01-01

Sustainable metabolic engineering for sustainability optimisation of industrial biotechnology

by Egils Stalidzans, Elina Dace
Published 2021-01-01

Coupling the endophytic microbiome with the host transcriptome in olive roots

by Antonio J. Fernández-González, Jorge A. Ramírez-Tejero, María Patricia Nevado-Berzosa, Francisco Luque, Manuel Fernández-López, Jesús Mercado-Blanco
Published 2021-01-01

Cryptic amyloidogenic regions in intrinsically disordered proteins: Function and disease association

by Jaime Santos, Irantzu Pallarès, Valentín Iglesias, Salvador Ventura
Published 2021-01-01

Binding affinity and mechanisms of SARS-CoV-2 variants

by Yanqiang Han, Zhilong Wang, Zhiyun Wei, Igor Schapiro, Jinjin Li
Published 2021-01-01

Application of long-read sequencing to the detection of structural variants in human cancer genomes

by Yoshitaka Sakamoto, Suzuko Zaha, Yutaka Suzuki, Masahide Seki, Ayako Suzuki
Published 2021-01-01

Mutperiod: Analysis of periodic mutation rates in nucleosomes

by Benjamin Morledge-Hampton, John J. Wyrick
Published 2021-01-01

Identify differential genes and cell subclusters from time-series scRNA-seq data using scTITANS

by Li Shao, Rui Xue, Xiaoyan Lu, Jie Liao, Xin Shao, Xiaohui Fan
Published 2021-01-01

MyoData: An expression knowledgebase at single cell/nucleus level for the discovery of coding-noncoding RNA functional interactions in skeletal muscle

by Davide Corso, Francesco Chemello, Enrico Alessio, Ilenia Urso, Giulia Ferrarese, Martina Bazzega, Chiara Romualdi, Gerolamo Lanfranchi, Gabriele Sales, Stefano Cagnin
Published 2021-01-01

Conformational transitions of caspase-6 in substrate-induced activation process explored by perturbation-response scanning combined with targeted molecular dynamics

by Shuheng Huang, Hu Mei, Laichun Lu, Zuyin Kuang, Yu Heng, Lei Xu, Xiaoqi Liang, Minyao Qiu, Xianchao Pan
Published 2021-01-01

MedProDB: A database of Mediator proteins

by Rohan Bhardwaj, Jitendra Kumar Thakur, Shailesh Kumar
Published 2021-01-01

Genome-wide mapping of binding sites of the transposase-derived SETMAR protein in the human genome

by Márton Miskei, Adrienn Horváth, Lívia Viola, Laura Varga, Éva Nagy, Orsolya Feró, Zsolt Karányi, Jason Roszik, Csaba Miskey, Zoltán Ivics, Lóránt Székvölgyi
Published 2021-01-01