Toward personalized TGFβ inhibition for pancreatic cancer

by Ryan M Carr, Martin E Fernandez‐Zapico
Published 2019-11-01

PATL2 is a key actor of oocyte maturation whose invalidation causes infertility in women and mice

by Marie Christou‐Kent, Zine‐Eddine Kherraf, Amir Amiri‐Yekta, Emilie Le Blévec, Thomas Karaouzène, Béatrice Conne, Jessica Escoffier, Said Assou, Audrey Guttin, Emeline Lambert, Guillaume Martinez, Magalie Boguenet, Selima Fourati Ben Mustapha, Isabelle Cedrin Durnerin, Lazhar Halouani, Ouafi Marrakchi, Mounir Makni, Habib Latrous, Mahmoud Kharouf, Charles Coutton, Nicolas Thierry‐Mieg, Serge Nef, Serge P Bottari, Raoudha Zouari, Jean Paul Issartel, Pierre F Ray, Christophe Arnoult
Published 2018-05-01

uPA‐PAI‐1 heteromerization promotes breast cancer progression by attracting tumorigenic neutrophils

by Bernd Uhl, Laura AMittmann, Julian Dominik, Roman Hennel, Bojan Smiljanov, Florian Haring, Johanna BSchaubächer, Constanze Braun, Lena Padovan, Robert Pick, Martin Canis, Christian Schulz, Matthias Mack, Ewgenija Gutjahr, Peter Sinn, Jörg Heil, Katja Steiger, Sandip M Kanse, Wilko Weichert, Markus Sperandio, Kirsten Lauber, Fritz Krombach, Christoph A Reichel
Published 2021-06-01

High‐throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts

by Emma Cretin, Priscilla Lopes, Elodie Vimont, Takashi Tatsuta, Thomas Langer, Anastasia Gazi, Martin Sachse, Patrick Yu‐Wai‐Man, Pascal Reynier, Timothy Wai
Published 2021-06-01

Machine learning algorithms reveal the secrets of mitochondrial dynamics

by Jack J Collier, Robert W Taylor
Published 2021-06-01

Human soluble ACE2 improves the effect of remdesivir in SARS‐CoV‐2 infection

by Vanessa Monteil, Matheus Dyczynski, Volker M Lauschke, Hyesoo Kwon, Gerald Wirnsberger, Sonia Youhanna, Haibo Zhang, Arthur S Slutsky, Carmen Hurtado del Pozo, Moritz Horn, Nuria Montserrat, Josef M Penninger, Ali Mirazimi
Published 2021-01-01

The riddle of the Sphinx: why sphingosine‐1‐phosphate may help define molecular mechanisms underlying risk stratification for serious COVID‐19 infections

by Hugh Rosen, Michael B A Oldstone
Published 2021-01-01

New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis, and therapy

by Zhuan Zhou, Furong Huang, Indira Shrivastava, Rui Zhu, Aiping Luo, Michael Hottiger, Ivet Bahar, Zhihua Liu, Massimo Cristofanilli, Yong Wan
Published 2020-12-01

SATB2 drives glioblastoma growth by recruiting CBP to promote FOXM1 expression in glioma stem cells

by Weiwei Tao, Aili Zhang, Kui Zhai, Zhi Huang, Haidong Huang, Wenchao Zhou, Qian Huang, Xiaoguang Fang, Briana C Prager, Xiuxing Wang, Qiulian Wu, Andrew E Sloan, Manmeet S Ahluwalia, Justin D Lathia, Jennifer S Yu, Jeremy N Rich, Shideng Bao
Published 2020-12-01

Altered bioenergetics and mitochondrial dysfunction of monocytes in patients with COVID‐19 pneumonia

by Lara Gibellini, Sara De Biasi, Annamaria Paolini, Rebecca Borella, Federica Boraldi, Marco Mattioli, Domenico Lo Tartaro, Lucia Fidanza, Alfredo Caro‐Maldonado, Marianna Meschiari, Vittorio Iadisernia, Erica Bacca, Giovanni Riva, Luca Cicchetti, Daniela Quaglino, Giovanni Guaraldi, Stefano Busani, Massimo Girardis, Cristina Mussini, Andrea Cossarizza
Published 2020-12-01

A comparative analysis of remdesivir and other repurposed antivirals against SARS‐CoV‐2

by Alexander Simonis, Sebastian J Theobald, Gerd Fätkenheuer, Jan Rybniker, Jakob J Malin
Published 2021-01-01

Psoriatic skin inflammation is promoted by c‐Jun/AP‐1‐dependent CCL2 and IL‐23 expression in dendritic cells

by Philipp Novoszel, Martin Holcmann, Gabriel Stulnig, Cristiano De Sa Fernandes, Victoria Zyulina, Izabela Borek, Markus Linder, Alexandra Bogusch, Barbara Drobits, Thomas Bauer, Carmen Tam‐Amersdorfer, Patrick M Brunner, Georg Stary, Latifa Bakiri, Erwin F Wagner, Herbert Strobl, Maria Sibilia
Published 2021-04-01

Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation

by Friederike Cuello, Anika E Knaust, Umber Saleem, Malte Loos, Janice Raabe, Diogo Mosqueira, Sandra Laufer, Michaela Schweizer, Petra van derKraak, Frederik Flenner, Bärbel M Ulmer, Ingke Braren, Xiaoke Yin, Konstantinos Theofilatos, Jorge Ruiz‐Orera, Giannino Patone, Birgit Klampe, Thomas Schulze, Angelika Piasecki, Yigal Pinto, Aryan Vink, Norbert Hübner, Sian Harding, Manuel Mayr, Chris Denning, Thomas Eschenhagen, Arne Hansen
Published 2021-06-01

High levels of circulating osteopontin in inflammatory lung disease regardless of Sars‐CoV‐2 infection

by Giuseppe Cappellano, Hugo Abreu, Davide Raineri, Lorenza Scotti, Luigi Castello, Rosanna Vaschetto, Annalisa Chiocchetti
Published 2021-05-01

Asymptomatic COVID‐19: disease tolerance with efficient anti‐viral immunity against SARS‐CoV‐2

by Yi‐Hao Chan, Siew‐Wai Fong, Chek‐Meng Poh, Guillaume Carissimo, Nicholas Kim‐Wah Yeo, Siti Naqiah Amrun, Yun Shan Goh, Jackwee Lim, Weili Xu, Rhonda Sin‐Ling Chee, Anthony Torres‐Ruesta, Cheryl Yi‐Pin Lee, Matthew Zirui Tay, Zi Wei Chang, Wen‐Hsin Lee, Bei Wang, Seow‐Yen Tan, Shirin Kalimuddin, Barnaby Edward Young, Yee‐Sin Leo, Cheng‐I Wang, Bernett Lee, Olaf Rötzschke, David Chien Lye, Laurent Renia, Lisa F P Ng
Published 2021-06-01

The respiratory syncytial virus (RSV) prefusion F‐protein functional antibody repertoire in adult healthy donors

by Emanuele Andreano, Ida Paciello, Monia Bardelli, Simona Tavarini, Chiara Sammicheli, Elisabetta Frigimelica, Silvia Guidotti, Giulia Torricelli, Marco Biancucci, Ugo D’Oro, Sumana Chandramouli, Matthew J Bottomley, Rino Rappuoli, Oretta Finco, Francesca Buricchi
Published 2021-06-01

Cooperation of LIM domain‐binding 2 (LDB2) with EGR in the pathogenesis of schizophrenia

by Tetsuo Ohnishi, Yuji Kiyama, Fumiko Arima‐Yoshida, Mitsutaka Kadota, Tomoe Ichikawa, Kazuyuki Yamada, Akiko Watanabe, Hisako Ohba, Kaori Tanaka, Akihiro Nakaya, Yasue Horiuchi, Yoshimi Iwayama, Manabu Toyoshima, Itone Ogawa, Chie Shimamoto‐Mitsuyama, Motoko Maekawa, Shabeesh Balan, Makoto Arai, Mitsuhiro Miyashita, Kazuya Toriumi, Yayoi Nozaki, Rumi Kurokawa, Kazuhiro Suzuki, Akane Yoshikawa, Tomoko Toyota, Toshihiko Hosoya, Hiroyuki Okuno, Haruhiko Bito, Masanari Itokawa, Shigehiro Kuraku, Toshiya Manabe, Takeo Yoshikawa
Published 2021-04-01

Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors

by Álvaro Lahiguera, Petra Hyroššová, Agnès Figueras, Diana Garzón, Roger Moreno, Vanessa Soto‐Cerrato, Iain McNeish, Violeta Serra, Conxi Lazaro, Pilar Barretina, Joan Brunet, Javier Menéndez, Xavier Matias‐Guiu, August Vidal, Alberto Villanueva, Barbie Taylor‐Harding, Hisashi Tanaka, Sandra Orsulic, Alexandra Junza, Oscar Yanes, Cristina Muñoz‐Pinedo, Luís Palomero, Miquel Àngel Pujana, José Carlos Perales, Francesc Viñals
Published 2020-06-01

Mannose receptor‐derived peptides neutralize pore‐forming toxins and reduce inflammation and development of pneumococcal disease

by Karthik Subramanian, Federico Iovino, Vasiliki Tsikourkitoudi, Padryk Merkl, Sultan Ahmed, Samuel B Berry, Marie‐Stephanie Aschtgen, Mattias Svensson, Peter Bergman, Georgios A Sotiriou, Birgitta Henriques‐Normark
Published 2020-11-01

Antioxidant nanozyme counteracts HIV‐1 by modulating intracellular redox potential

by Shalini Singh, Sourav Ghosh, Virender Kumar Pal, MohamedHusen Munshi, Pooja Shekar, Diwakar Tumkur Narasimha Murthy, Govindasamy Mugesh, Amit Singh
Published 2021-05-01