Structural Insights into CB1 Receptor Biased Signaling

by Rufaida Al-Zoubi, Paula Morales, Patricia H. Reggio
Published 2019-04-01

Ligand Bias and Its Association With Pro-resolving Actions of Melanocortin Drugs

by Sara Patruno, Sara Patruno, Sara Patruno, Jose Garrido-Mesa, Mario Romano, Mario Romano, Mauro Perretti, Mauro Perretti, Trinidad Montero-Melendez, Trinidad Montero-Melendez
Published 2018-08-01

Allosteric modulation of chemoattractant receptors

by Maria Candida Cesta, Marcello eAllegretti, Massimo eLocati, Massimo eLocati
Published 2016-05-01

Adenosine A_2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer’s Disease

by Rafael Franco, Rafael Rivas-Santisteban, Mireia Casanovas, Alejandro Lillo, Carlos A. Saura, Gemma Navarro
Published 2020-04-01

Evaluation of Functional Selectivity of Haloperidol, Clozapine, and LASSBio-579, an Experimental Compound With Antipsychotic-Like Actions in Rodents, at G Protein and Arrestin Sign...

by Rafaela R. Silva, Lucas T. Parreiras-e-Silva, Thais E.T. Pompeu, Diego A. Duarte, Carlos A.M. Fraga, Eliezer J. Barreiro, Ricardo Menegatti, Claudio M. Costa-Neto, François Noël
Published 2019-06-01

Personalized Medicine in Malignant Melanoma: Towards Patient Tailored Treatment

by Hildur Helgadottir, Hildur Helgadottir, Iara Rocha Trocoli Drakensjö, Iara Rocha Trocoli Drakensjö, Ada Girnita, Ada Girnita
Published 2018-06-01

Structure-Guided Computational Methods Predict Multiple Distinct Binding Modes for Pyrazoloquinolinones in GABAA Receptors

by Jure Fabjan, Filip Koniuszewski, Benjamin Schaar, Margot Ernst
Published 2021-01-01

Allosteric and biased G protein-coupled receptor signaling regulation: Potentials for new therapeutics

by Etienne eKhoury, Stéphanie eClément, Stéphane Alain Laporte
Published 2014-05-01

CB1 Cannabinoid Receptor Signaling and Biased Signaling

by Luciana M. Leo, Mary E. Abood
Published 2021-09-01

Functional Selectivity at the Dopamine D2 Receptor

by Peterson, Sean Michael
Published 2015

Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

by Rajendra Uprety, Tao Che, Saheem A Zaidi, Steven G Grinnell, Balázs R Varga, Abdelfattah Faouzi, Samuel T Slocum, Abdullah Allaoa, András Varadi, Melissa Nelson, Sarah M Bernhard, Elizaveta Kulko, Valerie Le Rouzic, Shainnel O Eans, Chloe A Simons, Amanda Hunkele, Joan Subrath, Ying Xian Pan, Jonathan A Javitch, Jay P McLaughlin, Bryan L Roth, Gavril W Pasternak, Vsevolod Katritch, Susruta Majumdar
Published 2021-02-01

Functional Selectivity and Antinociceptive Effects of a Novel KOPr Agonist

by Andrea Bedini, Lorenzo Di Cesare Mannelli, Laura Micheli, Monica Baiula, Gabriela Vaca, Rossella De Marco, Rossella De Marco, Luca Gentilucci, Carla Ghelardini, Santi Spampinato
Published 2020-03-01

Etude des bases structurales de l’efficacité et de la sélectivité fonctionnelle des récepteurs couplés aux protéines G : cas du récepteur V2 de la vasopressine

by Rahmeh, Rita
Published 2010

A Machine Learning Approach for the Discovery of Ligand-Specific Functional Mechanisms of GPCRs

by Ambrose Plante, Derek M. Shore, Giulia Morra, George Khelashvili, Harel Weinstein
Published 2019-06-01

Atypical Opioid Interactions – Development of Selective Mu-Delta Heterodimer Antagonists, Clinical Opioids at Non-Mu Pain Targets and Endogenous Biased Signaling

by Olson, Keith Mathew, Olson, Keith Mathew
Published 2017

Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D2 Dopamine Receptor

by Lani S. Chun, Rakesh H. Vekariya, R. Benjamin Free, Yun Li, Da-Ting Lin, Ping Su, Fang Liu, Yoon Namkung, Stephane A. Laporte, Amy E. Moritz, Jeffrey Aubé, Kevin J. Frankowski, David R. Sibley
Published 2018-02-01

Functional Selectivity Does Not Predict Antinociceptive/Locomotor Impairing Potencies of NOP Receptor Agonists

by Joaquim Azevedo Neto, Chiara Ruzza, Chiara Ruzza, Chiara Sturaro, Davide Malfacini, Salvatore Pacifico, Nurulain T. Zaveri, Girolamo Calò
Published 2021-03-01

Agonist bias and agonist‐dependent antagonism at corticotrophin releasing factor receptors

by Zoe Tasma, Peter Wills, Debbie L. Hay, Christopher S. Walker
Published 2020-06-01

The Gαi protein subclass selectivity to the dopamine D2 receptor is also decided by their location at the cell membrane

by Agnieszka Polit, Beata Rysiewicz, Paweł Mystek, Ewa Błasiak, Marta Dziedzicka-Wasylewska
Published 2020-12-01

BIASED AGONISM OF THREE DIFFERENT CANNABINOID RECEPTOR AGONISTS IN MOUSE BRAIN CORTEX

by Rebeca Diez-Alarcia, Rebeca Diez-Alarcia, Inés Ibarra-Lecue, Ángela Patricia López-Cardona, Ángela Patricia López-Cardona, Javier Meana, Javier Meana, Alfonso Gutierrez-Adán, Luis F Callado, Luis F Callado, Ekaitz Agirregoitia, Leyre Urigüen, Leyre Urigüen
Published 2016-11-01