Chromatin accessibility dynamics across C. elegans development and ageing

by Jürgen Jänes, Yan Dong, Michael Schoof, Jacques Serizay, Alex Appert, Chiara Cerrato, Carson Woodbury, Ron Chen, Carolina Gemma, Ni Huang, Djem Kissiov, Przemyslaw Stempor, Annette Steward, Eva Zeiser, Sascha Sauer, Julie Ahringer
Published 2018-10-01

A team of heterochromatin factors collaborates with small RNA pathways to combat repetitive elements and germline stress

by Alicia N McMurchy, Przemyslaw Stempor, Tessa Gaarenstroom, Brian Wysolmerski, Yan Dong, Darya Aussianikava, Alex Appert, Ni Huang, Paulina Kolasinska-Zwierz, Alexandra Sapetschnig, Eric A Miska, Julie Ahringer
Published 2017-03-01

MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance

by Israel Salguero, Rimma Belotserkovskaya, Julia Coates, Matylda Sczaniecka-Clift, Mukerrem Demir, Satpal Jhujh, Marcus D. Wilson, Stephen P. Jackson
Published 2019-11-01

Mechanical cell competition kills cells via induction of lethal p53 levels

by Laura Wagstaff, Maja Goschorska, Kasia Kozyrska, Guillaume Duclos, Iwo Kucinski, Anatole Chessel, Lea Hampton-O’Neil, Charles R. Bradshaw, George E. Allen, Emma L. Rawlins, Pascal Silberzan, Rafael E. Carazo Salas, Eugenia Piddini
Published 2016-04-01

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

by Gabriel Balmus, Domenic Pilger, Julia Coates, Mukerrem Demir, Matylda Sczaniecka-Clift, Ana C. Barros, Michael Woods, Beiyuan Fu, Fengtang Yang, Elisabeth Chen, Matthias Ostermaier, Tatjana Stankovic, Hannes Ponstingl, Mareike Herzog, Kosuke Yusa, Francisco Munoz Martinez, Stephen T. Durant, Yaron Galanty, Petra Beli, David J. Adams, Allan Bradley, Emmanouil Metzakopian, Josep V. Forment, Stephen P. Jackson
Published 2019-01-01

Epigenetic homogeneity in histone methylation underlies sperm programming for embryonic transcription

by Mami Oikawa, Angela Simeone, Eva Hormanseder, Marta Teperek, Vincent Gaggioli, Alan O’Doherty, Emma Falk, Matthieu Sporniak, Clive D’Santos, Valar Nila Roamio Franklin, Kamal Kishore, Charles R. Bradshaw, Declan Keane, Thomas Freour, Laurent David, Adrian T. Grzybowski, Alexander J. Ruthenburg, John Gurdon, Jerome Jullien
Published 2020-07-01

Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids

by Marko Z Nikolić, Oriol Caritg, Quitz Jeng, Jo-Anne Johnson, Dawei Sun, Kate J Howell, Jane L Brady, Usua Laresgoiti, George Allen, Richard Butler, Matthias Zilbauer, Adam Giangreco, Emma L Rawlins
Published 2017-06-01

Tracing the transitions from pluripotency to germ cell fate with CRISPR screening

by Jamie A. Hackett, Yun Huang, Ufuk Günesdogan, Kristjan A. Gretarsson, Toshihiro Kobayashi, M. Azim Surani
Published 2018-10-01

PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1

by Rimma Belotserkovskaya, Elisenda Raga Gil, Nicola Lawrence, Richard Butler, Gillian Clifford, Marcus D. Wilson, Stephen P. Jackson
Published 2020-02-01

Publisher Correction: Tracing the transitions from pluripotency to germ cell fate with CRISPR screening

by Jamie A. Hackett, Yun Huang, Ufuk Günesdogan, Kristjan A. Gretarsson, Toshihiro Kobayashi, M. Azim Surani
Published 2018-12-01

Parallel CRISPR-Cas9 screens clarify impacts of p53 on screen performance

by Anne Ramsay Bowden, David A Morales-Juarez, Matylda Sczaniecka-Clift, Maria Martin Agudo, Natalia Lukashchuk, John Christopher Thomas, Stephen P Jackson
Published 2020-05-01

bicoid mRNA localises to the Drosophila oocyte anterior by random Dynein-mediated transport and anchoring

by Vítor Trovisco, Katsiaryna Belaya, Dmitry Nashchekin, Uwe Irion, George Sirinakis, Richard Butler, Jack J Lee, Elizabeth R Gavis, Daniel St Johnston
Published 2016-10-01

APP Metabolism Regulates Tau Proteostasis in Human Cerebral Cortex Neurons

by Steven Moore, Lewis D.B. Evans, Therese Andersson, Erik Portelius, James Smith, Tatyana B. Dias, Nathalie Saurat, Amelia McGlade, Peter Kirwan, Kaj Blennow, John Hardy, Henrik Zetterberg, Frederick J. Livesey
Published 2015-05-01

A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons

by Anastasiya Sybirna, Walfred W. C. Tang, Merrick Pierson Smela, Sabine Dietmann, Wolfram H. Gruhn, Ran Brosh, M. Azim Surani
Published 2020-03-01

Cysteine synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection

by Nicholas O. Burton, Cristian Riccio, Alexandra Dallaire, Jonathan Price, Benjamin Jenkins, Albert Koulman, Eric A. Miska
Published 2020-04-01

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

by Gabriel Balmus, Delphine Larrieu, Ana C. Barros, Casey Collins, Monica Abrudan, Mukerrem Demir, Nicola J. Geisler, Christopher J. Lelliott, Jacqueline K. White, Natasha A. Karp, James Atkinson, Andrea Kirton, Matt Jacobsen, Dean Clift, Raphael Rodriguez, Sanger Mouse Genetics Project, David J. Adams, Stephen P. Jackson
Published 2018-04-01

Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status

by Iwo Kucinski, Michael Dinan, Golnar Kolahgar, Eugenia Piddini
Published 2017-07-01

Neddylation Promotes Ubiquitylation and Release of Ku from DNA-Damage Sites

by Jessica S. Brown, Natalia Lukashchuk, Matylda Sczaniecka-Clift, Sébastien Britton, Carlos le Sage, Patrick Calsou, Petra Beli, Yaron Galanty, Stephen P. Jackson
Published 2015-05-01

DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans

by Kin Man Suen, Fabian Braukmann, Richard Butler, Dalila Bensaddek, Alper Akay, Chi-Chuan Lin, Dovilė Milonaitytė, Neel Doshi, Alexandra Sapetschnig, Angus Lamond, John Edward Ladbury, Eric Alexander Miska
Published 2020-08-01

A network approach to mixing delegates at meetings

by Federico Vaggi, Tommaso Schiavinotto, Jonathan LD Lawson, Anatole Chessel, James Dodgson, Marco Geymonat, Masamitsu Sato, Rafael Edgardo Carazo Salas, Attila Csikász-Nagy
Published 2014-02-01