Histological Evidence of Protein Aggregation in Mutant SOD1 Transgenic Mice and in Amyotrophic Lateral Sclerosis Neural Tissues

by Mitsunori Watanabe, Margaret Dykes-Hoberg, Valeria Cizewski Culotta, Donald L. Price, Philip C. Wong, Jeffrey D. Rothstein
Published 2001-12-01

Ion-Complex Microcrystal Formulation Provides Sustained Delivery of a Multimodal Kinase Inhibitor from the Subconjunctival Space for Protection of Retinal Ganglion Cells

by Henry T. Hsueh, Yoo-Chun Kim, Ian Pitha, Matthew D. Shin, Cynthia A. Berlinicke, Renee Ti Chou, Elizabeth Kimball, Julie Schaub, Sarah Quillen, Kirby T. Leo, Hyounkoo Han, Amy Xiao, Youngwook Kim, Matthew Appell, Usha Rai, HyeYoung Kwon, Patricia Kolodziejski, Laolu Ogunnaike, Nicole M. Anders, Avelina Hemingway, Joan L. Jefferys, Abhijit A. Date, Charles Eberhart, Thomas V. Johnson, Harry A. Quigley, Donald J. Zack, Justin Hanes, Laura M. Ensign
Published 2021-05-01

A miniature multi-contrast microscope for functional imaging in freely behaving animals

by Janaka Senarathna, Hang Yu, Callie Deng, Alice L. Zou, John B. Issa, Darian H. Hadjiabadi, Stacy Gil, Qihong Wang, Betty M. Tyler, Nitish V. Thakor, Arvind P. Pathak
Published 2019-01-01

ASCOT identifies key regulators of neuronal subtype-specific splicing

by Jonathan P. Ling, Christopher Wilks, Rone Charles, Patrick J. Leavey, Devlina Ghosh, Lizhi Jiang, Clayton P. Santiago, Bo Pang, Anand Venkataraman, Brian S. Clark, Abhinav Nellore, Ben Langmead, Seth Blackshaw
Published 2020-01-01

Precardiac organoids form two heart fields via Bmp/Wnt signaling

by Peter Andersen, Emmanouil Tampakakis, Dennisse V. Jimenez, Suraj Kannan, Matthew Miyamoto, Hye Kyung Shin, Amir Saberi, Sean Murphy, Edrick Sulistio, Stephen P. Chelko, Chulan Kwon
Published 2018-08-01

Diagnostic potential of tumor DNA from ovarian cyst fluid

by Yuxuan Wang, Karin Sundfeldt, Constantina Mateoiu, Ie-Ming Shih, Robert J Kurman, Joy Schaefer, Natalie Silliman, Isaac Kinde, Simeon Springer, Michael Foote, Björg Kristjansdottir, Nathan James, Kenneth W Kinzler, Nickolas Papadopoulos, Luis A Diaz, Bert Vogelstein
Published 2016-07-01

Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway

by Yuta Hatori, Ye Yan, Katharina Schmidt, Eri Furukawa, Nesrin M. Hasan, Nan Yang, Chin-Nung Liu, Shanthini Sockanathan, Svetlana Lutsenko
Published 2016-02-01

Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor

by Jing Li, Jordan T White, Harry Saavedra, James O Wrabl, Hesam N Motlagh, Kaixian Liu, James Sowers, Trina A Schroer, E Brad Thompson, Vincent J Hilser
Published 2017-10-01

DISC1-mediated dysregulation of adult hippocampal neurogenesis in rats

by Heekyung eLee, Eunchai eKang, Eunchai eKang, Douglas eGoodSmith, Do Yeon eYoon, Hongjun eSong, Hongjun eSong, Hongjun eSong, James J. Knierim, James J. Knierim, Guo-li eMing, Guo-li eMing, Guo-li eMing, Guo-li eMing, Kimberly M. Christian, Kimberly M. Christian
Published 2015-06-01

Epigenetically regulated digital signaling defines epithelial innate immunity at the tissue level

by Helen R. Clark, Connor McKenney, Nathan M. Livingston, Ariel Gershman, Seema Sajjan, Isaac S. Chan, Andrew J. Ewald, Winston Timp, Bin Wu, Abhyudai Singh, Sergi Regot
Published 2021-03-01

Deep learning for diagnosis of acute promyelocytic leukemia via recognition of genomically imprinted morphologic features

by John-William Sidhom, Ingharan J. Siddarthan, Bo-Shiun Lai, Adam Luo, Bryan C. Hambley, Jennifer Bynum, Amy S. Duffield, Michael B. Streiff, Alison R. Moliterno, Philip Imus, Christian B. Gocke, Lukasz P. Gondek, Amy E. DeZern, Alexander S. Baras, Thomas Kickler, Mark J. Levis, Eugene Shenderov
Published 2021-05-01

UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction

by Benjamin L. Zaepfel, Zhe Zhang, Kirstin Maulding, Alyssa N. Coyne, Weiwei Cheng, Lindsey R. Hayes, Thomas E. Lloyd, Shuying Sun, Jeffrey D. Rothstein
Published 2021-03-01

Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid β peptide in APPswe transgenic mice

by Jin G Sheng, Susan H Bora, G Xu, David R Borchelt, Donald L Price, Vassilis E Koliatsos
Published 2003-10-01

Corrigendum to “Expression of mutant DISC1 in Purkinje cells increases their spontaneous activity and impairs cognitive and social behaviors in mice” [Neurobiol. Dis. 103 (2017) 14...

by Alexey V. Shevelkin, Chantelle E. Terrillion, Bagrat N. Abazyan, Tymoteusz J. Kajstura, Yan A. Jouroukhin, Gay L. Rudow, Juan C. Troncoso, David J. Linden, Mikhail V. Pletnikov
Published 2017-12-01

Mechanical stress determines the configuration of TGFβ activation in articular cartilage

by Gehua Zhen, Qiaoyue Guo, Yusheng Li, Chuanlong Wu, Shouan Zhu, Ruomei Wang, X. Edward Guo, Byoung Choul Kim, Jessie Huang, Yizhong Hu, Yang Dan, Mei Wan, Taekjip Ha, Steven An, Xu Cao
Published 2021-03-01

Methylated cis-regulatory elements mediate KLF4-dependent gene transactivation and cell migration

by Jun Wan, Yijing Su, Qifeng Song, Brian Tung, Olutobi Oyinlade, Sheng Liu, Mingyao Ying, Guo-li Ming, Hongjun Song, Jiang Qian, Heng Zhu, Shuli Xia
Published 2017-05-01

Takotsubo Syndrome in the Setting of COVID-19

by Anum S. Minhas, MD, Paul Scheel, MD, Brian Garibaldi, MD, Gigi Liu, MD, MS, Maureen Horton, MD, Mark Jennings, MD, MHS, Steven R. Jones, MD, Erin D. Michos, MD, MHS, Allison G. Hays, MD
Published 2020-07-01

PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2

by Sean A. Murphy, Matthew Miyamoto, Anaïs Kervadec, Suraj Kannan, Emmanouil Tampakakis, Sandeep Kambhampati, Brian Leei Lin, Sam Paek, Peter Andersen, Dong-Ik Lee, Renjun Zhu, Steven S. An, David A. Kass, Hideki Uosaki, Alexandre R. Colas, Chulan Kwon
Published 2021-03-01

Detection and characterization of lung cancer using cell-free DNA fragmentomes

by Dimitrios Mathios, Jakob Sidenius Johansen, Stephen Cristiano, Jamie E. Medina, Jillian Phallen, Klaus R. Larsen, Daniel C. Bruhm, Noushin Niknafs, Leonardo Ferreira, Vilmos Adleff, Jia Yuee Chiao, Alessandro Leal, Michael Noe, James R. White, Adith S. Arun, Carolyn Hruban, Akshaya V. Annapragada, Sarah Østrup Jensen, Mai-Britt Worm Ørntoft, Anders Husted Madsen, Beatriz Carvalho, Meike de Wit, Jacob Carey, Nicholas C. Dracopoli, Tara Maddala, Kenneth C. Fang, Anne-Renee Hartman, Patrick M. Forde, Valsamo Anagnostou, Julie R. Brahmer, Remond J. A. Fijneman, Hans Jørgen Nielsen, Gerrit A. Meijer, Claus Lindbjerg Andersen, Anders Mellemgaard, Stig E. Bojesen, Robert B. Scharpf, Victor E. Velculescu
Published 2021-08-01

Supervised dimensionality reduction for big data

by Joshua T. Vogelstein, Eric W. Bridgeford, Minh Tang, Da Zheng, Christopher Douville, Randal Burns, Mauro Maggioni
Published 2021-05-01