Comparison of programmed death-ligand 1 protein expression between primary and metastatic lesions in patients with lung cancer

by Lajos Pusztai, Richard Huang, Shakti Ramkissoon, Jeffrey S Ross, Konstantinos Syrigos, Myrto K Moutafi, Weiwei Tao, James Haberberger, Ioannis A Vathiotis
Published 2021-04-01

Adrenal gland as a sanctuary site for immunotherapy in patients with microsatellite instability-high metastatic colorectal cancer

by Romain Cohen, Vincent Jonchère, Toky Ratovomanana, Quentin Letourneur, Mira Ayadi, Lucile Armenoult, Adrien Buisson, Matthieu Sarabi, Anna Pellat, Francois Paye, Alex Duval
Published 2021-02-01

Integrative transcriptome analysis of malignant pleural mesothelioma reveals a clinically relevant immune-based classification

by Victor Moreno, Ania Alay, David Cordero, Sara Hijazo-Pechero, Elisabet Aliagas, Adriana Lopez-Doriga, Raúl Marín, Ramón Palmero, Roger Llatjós, Ignacio Escobar, Ricard Ramos, Susana Padrones, Xavier Solé
Published 2021-02-01

Post-transplantation cyclophosphamide reduces the incidence of acute graft-versus-host disease in patients with acute myeloid leukemia/myelodysplastic syndromes who receive immune...

by Maro Ohanian, Farhad Ravandi, Maria E Suarez-Almazor, Noha Abdel-Wahab, Houssein Safa, Ala Abudayyeh, Stephen Gruschkus, May Daher, Richard Champlin, Kaysia Ludford, Guillermo Garcia-Manero, Hind Rafei, Jacinth Joseph, Gabriela Rondon, Laura Whited, Faisal Fa'ak, Cristina Knape, Mahran Shoukier, Megan Marcotulli, Alison M Gulbis, Betul Oran, Uday R Popat, Rotesh Mehta, Amin M Alousi
Published 2021-02-01

CXCL9-expressing tumor-associated macrophages: new players in the fight against cancer

by Shahram Salek-Ardakani, Paola Marie Marcovecchio, Graham Thomas
Published 2021-02-01

Frequent amplification of HDAC genes and efficacy of HDAC inhibitor chidamide and PD-1 blockade combination in soft tissue sarcoma

by Ze-Xian Liu, Wei Xiao, Jing-Jing Zhao, Qiu-Zhong Pan, De-Sheng Weng, Yi Que, Xiao-Long Zhang, Xi-Zhi Wen, Bu-Shu Xu, Dong-Chun Hong, Tian-Hui Guo, Lu-Jun Shen, Wei-Jun Fan, Huo-Ying Chen, Hai-Rong Xu, Peng-Hui Zhou, Yi-Zhuo Zhang, Xiao-Hui Niu, Xing Zhang
Published 2021-02-01

TGFβ1 neutralization displays therapeutic efficacy through both an immunomodulatory and a non-immune tumor-intrinsic mechanism

by Stefania Canè, Jacques Van Snick, Catherine Uyttenhove, Luc Pilotte
Published 2021-02-01

Radiological dynamics and SITC-defined resistance types of advanced melanoma during anti-PD-1 monotherapy: an independent single-blind observational study on an international cohor...

by Xiaoling Yang, Keith Flaherty, Jun Guo, Xue Bai, Michelle Kim, Gyulnara Kasumova, Lu Si, Bixia Tang, Chuanliang Cui, Xiaoting Wei, Donald Lawrence, Christine Freedman, Riley Fadden, Krista Rubin, Tatyana Sharova, Dennie Frederick, Genevieve Boland
Published 2021-02-01

Multiomics analysis reveals a distinct response mechanism in multiple primary lung adenocarcinoma after neoadjuvant immunotherapy

by Jian Su, Yi-Long Wu, Xu-Chao Zhang, Kai Yin, Si-Yang Liu, Li-Xu Yan, Xue-Ning Yang
Published 2021-04-01

Improved clinical outcome in a randomized phase II study of anti-PD-1 camrelizumab plus decitabine in relapsed/refractory Hodgkin lymphoma

by Weidong Han, Malcolm Brock, Chunmeng Wang, Liang Dong, Qingming Yang, Meixia Chen, Fengxia Shi, Jiejie Liu
Published 2021-04-01

Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose?

by Sandra Demaria, C Norman Coleman, Jonathan Schoenfeld, Arta Monjazeb, Samir Khleif, Seema Gupta, Andrew Sikora, Zachary Morris, Chandan Guha, Stephen Shiao, Silvia Chiara Formenti, Bhadrasain Vikram, Mansoor M Ahmed
Published 2021-04-01

Oncolytic herpesvirus expressing PD-L1 BiTE for cancer therapy: exploiting tumor immune suppression as an opportunity for targeted immunotherapy

by Hena Khalique, Richard Baugh, Arthur Dyer, Eleanor M. Scott, Sally Frost, Sarah Larkin, Janet Lei-Rossmann, Leonard W. Seymour
Published 2021-04-01

Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade

by Marcin Kowanetz, Thomas Powles, Hartmut Koeppen, Jane Grogan, Patrick Caplazi, Ira Mellman, Wei Zou, Sanjeev Mariathasan, Priti S. Hegde, Mark McCleland, Jacqueline McBride, Zora Modrusan, Romain Banchereau, Avantika S. Chitre, Alexis Scherl, Thomas D. Wu, Namrata S. Patil, Patricia de Almeida, Edward E. Kadel, III, Shravan Madireddi, Amelia Au-Yeung, Chikara Takahashi, Ying-Jiun Chen, Rhea Nersesian, Ehab A. El-Gabry, Mark D. Robida, Jeffrey C. Hung, Shadi Toghi Eshgi, W. Rodney Mathews, William E O'Gorman
Published 2021-04-01

STING agonist-based treatment promotes vascular normalization and tertiary lymphoid structure formation in the therapeutic melanoma microenvironment

by Walter J Storkus, Ronald J Fecek, Manoj Chelvanambi, Jennifer L Taylor
Published 2021-02-01

Differential combination immunotherapy requirements for inflamed (warm) tumors versus T cell excluded (cool) tumors: engage, expand, enable, and evolve

by Kellsye P Fabian
Published 2021-02-01

In silico trials predict that combination strategies for enhancing vesicular stomatitis oncolytic virus are determined by tumor aggressivity

by Adrianne L Jenner, Tyler Cassidy, Katia Belaid, Morgan Craig
Published 2021-02-01

Real-world insights on preferred treatments for steroid-refractory immune checkpoint inhibitor-induced pneumonitis

by Margaret Gatti-Mays
Published 2021-02-01

Real-world survival outcomes with immune checkpoint inhibitors in large-cell neuroendocrine tumors of lung

by Stephen V Liu, Elizabeth Dudnik, Mor Moskovitz, Anastasiya Lobachov, Teodor Gottfried, Damien Urban, Ofer Rotem, Mira Wollner
Published 2021-02-01

Intratumoral CXCL13+CD8+T cell infiltration determines poor clinical outcomes and immunoevasive contexture in patients with clear cell renal cell carcinoma

by Jiejie Xu, Yu Xia, Ying Xiong, Yu Zhu, Zewei Wang, Han Zeng, Zhaopei Liu, Jiajun Wang, Yuan Chang, Le Xu, Qi Bai, Jianming Guo, Siyuan Dai, Kaifeng Jin, Wenbin Jiang, Zhiyuan Lin, Yang Qu
Published 2021-02-01

Mesenchymal stem cells and oncolytic viruses: joining forces against cancer

by Rafael Moreno
Published 2021-02-01